Biological processes and key druggable targets involved in age-associated memory loss: A systematic review
| Autor: | S. Sajithalulu, Girinath G. Pillai, P. Ambili Unni |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Proteomics Aging Population Druggability Normal aging Biology 030226 pharmacology & pharmacy General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Humans Cholesterol metabolism General Pharmacology Toxicology and Pharmaceutics education Biological Phenomena education.field_of_study Memory Disorders Genome Neurodegenerative Diseases General Medicine Genomics Hormones Oxidative Stress 030104 developmental biology Cholesterol Calcium Neuroscience |
| Zdroj: | Life sciences. 270 |
| ISSN: | 1879-0631 |
| Popis: | Age-associated memory loss is highly prevalent in the elder population. The inception of neurodegenerative diseases acts as a causative factor for the onset of memory loss in aged individuals. The pathophysiological mechanisms of memory loss associated with the onset of neurodegenerative diseases and normal aging processes share certain similarities as well as differences. The normal age-associated memory loss is attributed to the impairment of calcium metabolism, dysregulated cholesterol metabolism, the prevalence of oxidative stress, inappropriate functioning of hormones as well as genetic factors. Vital information regarding the key biological processes and the druggable targets involved in the onset of memory loss in the elder population has been provided in this article. The genomic and proteomic profiles of key druggable targets retrieved from the experimental evidence, co-expression studies and databases are also presented in this article. The genomic and proteomic information of druggable targets will aid in the identification of therapeutic agents which could effectively regulate the key biological processes involved in the age-associated memory loss. |
| Databáze: | OpenAIRE |
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