DNA vaccines for allergy treatment
Autor: | Josef Thalhamer, Sandra Scheiblhofer, Romana Hochreiter, Richard Weiss, Arnulf Josef Hartl |
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Rok vydání: | 2003 |
Předmět: |
Allergy
medicine.medical_treatment Immunogenicity Cancer Immunotherapy Biology Allergens medicine.disease Virology General Biochemistry Genetics and Molecular Biology Recombinant Proteins beta-N-Acetylhexosaminidases DNA vaccination Rats Vaccination Immune system Leukemia Basophilic Acute Immunology medicine Hypersensitivity Vaccines DNA Animals Humans Molecular Biology Gene |
Zdroj: | Methods (San Diego, Calif.). 32(3) |
ISSN: | 1046-2023 |
Popis: | In the past 10 years, a great number of studies have demonstrated that injection of plasmid DNA coding for certain genes results in the induction of humoral and cellular immune responses against the respective gene product. This vaccination approach covers a broad range of possible applications, including the induction of protective immunity against viral, bacterial, and parasitic infections, and it opens new perspectives for treatment of cancer. Surprisingly, DNA immunization also turned out as a promising novel type of immunotherapy against allergy. In this paper, we describe the construction of DNA vaccines for application in allergy models. Beyond, we offer a palette of recently developed modulations to optimize DNA vaccines for allergy treatment by increasing their immunogenicity and minimizing their anaphylactic potential. |
Databáze: | OpenAIRE |
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