Effects of Zao Huang Mixture () on the Expressions of TGF-β1 and Col IV in Human Glomerular Mesangial Cells Cultured in High Glucose Environment
| Autor: | Lei-xiu Deng, Cong-kui Lü, Xiao-yan Sun, Jian-wei Ju, Shou-han Mu, Yan-zhi Yin |
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| Rok vydání: | 2011 |
| Předmět: |
Collagen Type IV
medicine.medical_specialty Primary culture Zao Huang Mixture (ZHM) Glomerular Mesangial Cell Transforming Growth Factor beta1 Diabetic nephropathy Internal medicine Chinese traditional collagen IV medicine Humans Diabetic Nephropathies Medicine Chinese Traditional transforming growth factor-β1 Cells Cultured Medicine(all) human glomerular mesangial cells business.industry General Medicine medicine.disease In vitro Normal group Glucose Endocrinology high glucose environment Mesangial Cells High glucose business Transforming growth factor |
| Zdroj: | Journal of Traditional Chinese Medicine. 31:127-129 |
| ISSN: | 0254-6272 |
| DOI: | 10.1016/s0254-6272(11)60026-5 |
| Popis: | ObjectiveTo investigate the effect of Zao Huang Mixture (ZHM) on expressions of growth factor-β1 (TGF-β1) and collagen IV (Col IV) in human glomerular mesangial cells (GMC) cultured in high-glucose environment.MethodsAfter primary culture of GMC, in vitro culture was carried out in normal group, high glucose group and high glucose medium with ZHM of different concentrations, and the expressions of TGF-β1 and Col IV in the GMC group and in ZHM group were detected at 24 and 48 h respectively.ResultsCompared with the normal group, expressions of TGF-β1 and Col IV significantly increased at 24 h, 48 h in the high glucose group (all P |
| Databáze: | OpenAIRE |
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