Antibiotic Resistance of Bacteria Involved in Urinary Infections in Brazil: A Cross-Sectional and Retrospective Study
| Autor: | Javier Emilio Lazo-Chica, Wellington Francisco Rodrigues, Carlo José Freire Oliveira, Ana Paula Oliveira Nogueira, Camila Botelho Miguel, Elisabete Aparecida Mantovani Rodrigues De Resende, Marcelo Costa Araújo, Carlos Ueira-Vieira, Siomar de Castro Soares, Tony De Paiva Paulino |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.drug_class Health Toxicology and Mutagenesis 030106 microbiology Antibiotics lcsh:Medicine Microbial Sensitivity Tests Biology Article antibiotics Microbiology 03 medical and health sciences 0302 clinical medicine Antibiotic resistance Ciprofloxacin Ampicillin Drug Resistance Bacterial Escherichia coli medicine Humans urinary infection 030212 general & internal medicine bacterial resistance Escherichia coli Infections Norfloxacin Retrospective Studies lcsh:R Public Health Environmental and Occupational Health Sulbactam biochemical phenomena metabolism and nutrition Antimicrobial bacterial infections and mycoses Anti-Bacterial Agents Cross-Sectional Studies Nitrofurantoin Urinary Tract Infections Brazil Fluoroquinolones medicine.drug |
| Zdroj: | International Journal of Environmental Research and Public Health; Volume 13; Issue 9; Pages: 918 International Journal of Environmental Research and Public Health, Vol 13, Iss 9, p 918 (2016) International Journal of Environmental Research and Public Health |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph13090918 |
| Popis: | Empirical and prolonged antimicrobial treatment of urinary tract infections caused by Escherichia coli is associated with the emergence of bacterial resistance, and not all countries have strict policies against the indiscriminate use of drugs in order to prevent resistance. This cross-sectional and retrospective study (2010–2015) aimed to evaluate the sensitivity and resistance of patient-derived E. coli to different drugs broadly used to treat urinary infections in Brazil: ampicillin + sulbactam, cephalothin, ciprofloxacin, norfloxacin, and nitrofurantoin. We obtained 1654 E. coli samples from ambulatory patients with disease symptoms of the urinary tract from a Brazilian public hospital. While all antibiotics were effective in killing E. coli to a large degree, nitrofurantoin was the most effective, with fewer samples exhibiting antibiotic resistance. We assessed the costs of generic and brand name versions of each antibiotic. Nitrofurantoin, the most effective antibiotic, was the cheapest, followed by the fluoroquinolones (ciprofloxacin and norfloxacin), ampicillin + sulbactam and, lastly, cephalothin. Finally, assessment of antibiotic resistance to fluoroquinolones over the study period and extrapolation of the data led to the conclusion that these antibiotics could no longer be effective against E. coli-based urinary infections in approximately 20 years if their indiscriminate use in empirical treatment continues. |
| Databáze: | OpenAIRE |
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