Behavioral and neurobiological characteristics influencing social hierarchy formation in female cynomolgus monkeys
| Autor: | Pradeep Garg, Sudha Garg, Natallia V. Riddick, Michael A. Nader, Jay R. Kaplan, H.D. Gage, Michelle Icenhower, Susan H. Nader, Paul W. Czoty, Allyson J. Bennett, Peter J. Pierre |
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| Rok vydání: | 2009 |
| Předmět: |
Dominance-Subordination
Benzylamines Serotonin medicine.medical_specialty Time Factors Hydrocortisone Adrenocorticotropic hormone Motor Activity Article Dexamethasone chemistry.chemical_compound Neurochemical Adrenocorticotropic Hormone Internal medicine Reaction Time medicine Animals Neurotransmitter Glucocorticoids 5-HT receptor Serotonin Plasma Membrane Transport Proteins Analysis of Variance Carbon Isotopes Behavior Animal General Neuroscience Brain Hydroxyindoleacetic Acid Macaca fascicularis Endocrinology chemistry Positron-Emission Tomography Exploratory Behavior Female Analysis of variance Psychology medicine.drug Hormone |
| Zdroj: | Neuroscience. 158:1257-1265 |
| ISSN: | 0306-4522 |
| DOI: | 10.1016/j.neuroscience.2008.11.016 |
| Popis: | Socially housed monkeys have been used as a model to study human diseases. The present study examined behavioral, physiological and neurochemical measures as predictors of social rank in sixteen experimentally naïve, individually housed female cynomolgus monkeys (Macaca fascicularis). The two behavioral measures examined were novel-object reactivity (NOR), as determined by latency to touch an opaque acrylic box placed in the home cage, and locomotor activity assessed in a novel open-field apparatus. Serum cortisol concentrations were evaluated three times per week for four consecutive weeks, and stress reactivity was assessed on one occasion by evaluating the cortisol response to adrenocorticotropic hormone (ACTH) following dexamethasone suppression. Measures of serotonin function included whole blood serotonin (WBS) concentrations, cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) and brain serotonin transporter (SERT) availability obtained using positron emission tomography (PET). After baseline measures were obtained, monkeys were assigned to four social groups of four monkeys per group. The two measures that correlated with social rank were CSF 5-HIAA concentrations, which were significantly higher in the animals who eventually became subordinate and latency to touch the novel object, which was significantly lower in eventual subordinate monkeys. Measures of serotonin function did not change as a consequence of social rank. These data suggest that levels of central 5-HIAA and measures of novel object reactivity may be trait markers that influence eventual social rank in female macaques. |
| Databáze: | OpenAIRE |
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