Addition of grapes to both a standard and a high-fat Western pattern diet modifies hepatic and urinary metabolite profiles in the mouse

Autor:	Diren Beyoğlu, Eun-Jung Park, Adolfo Quiñones-Lombraña, Asim Dave, Falguni Parande, John M. Pezzuto, Jeffrey R. Idle
Rok vydání:	2022
Předmět:	Mice Inbred C57BL Mice Glucose Liver Animals Female Vitis General Medicine Powders Diet High-Fat Food Science
Zdroj:	Food & Function. 13:8489-8499
ISSN:	2042-650X 2042-6496
DOI:	10.1039/d2fo00961g
Popis:	The benefits of fruit and vegetable dietary consumption are largely defined in epidemiological terms. Relatively little is known about the discrete effects on metabolic pathways elicited by individual dietary fruits and vegetables. To address this, grape powder was added to both a standard and a high-fat Western pattern diet given to 10-week-old female C57BL/6J mice for a period of 91 days, whereupon 24 h urines were collected and the mice euthanized after a 12 h fast for the collection of liver tissue. Alterations in hepatic and urinary metabolite patterns were determined by gas chromatography-mass spectrometry-based metabolomics. Urinary excretion of the gut microbiota metabolites 4-hydroxyphenylacetic acid, 5-hydroxyindole, glyceric acid, gluconic acid and
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65185c1fd048d03edb25b4b9a1084c4c https://doi.org/10.1039/d2fo00961g Zobrazit plný text záznamu