Decreased medial entorhinal cortical thickness in olanzapine exposed female rats is not ameliorated by exercise
| Autor: | Melissa L. Woodward, Christa Hercher, William G. Honer, Heidi N. Boyda, A.H. Ker, Clare L. Beasley, Ric M. Procyshyn, Donna J. Lang, Alasdair M. Barr |
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| Rok vydání: | 2019 |
| Předmět: |
Olanzapine
medicine.medical_specialty Psychosis medicine.medical_treatment Clinical Biochemistry Hippocampus Toxicology Biochemistry Rats Sprague-Dawley 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Internal medicine Physical Conditioning Animal Neuroplasticity medicine Aerobic exercise Animals Entorhinal Cortex Antipsychotic Biological Psychiatry Pharmacology business.industry Entorhinal cortex medicine.disease Brain Cortical Thickness 030227 psychiatry Rats Endocrinology Female Analysis of variance Sedentary Behavior business 030217 neurology & neurosurgery medicine.drug Antipsychotic Agents |
| Zdroj: | Pharmacology, biochemistry, and behavior. 188 |
| ISSN: | 1873-5177 |
| Popis: | Aerobic exercise has been associated with hippocampal plasticity, both in healthy adults and in psychosis patients, but its impact on cortical regions remains unclear. The entorhinal cortex serves as a critical gateway for the hippocampus, and recent studies suggest that this region may also be impacted following an exercise regime. In order to investigate the effects of antipsychotic medications and exercise on the entorhinal cortex, female rats were chronically administered either olanzapine or vehicle and were either sedentary or had access to a running wheel for 9 weeks. Olanzapine-treated rats had decreased medial entorhinal cortical thickness compared to vehicle-treated rats. A statistically significant interaction was observed for layer II of the entorhinal cortex, with exercising rats having significantly greater thickness compared to sedentary rats in the vehicle group, but not the olanzapine group. Greater total entorhinal and lateral entorhinal cortical thickness was associated with greater average activity. In exercising rats, decreasing glucose intolerance was associated with larger total entorhinal and layer II cortical thickness. Lower fasting insulin levels were associated with greater total entorhinal, lateral entorhinal, and layer II cortical thickness. The relationship between increased activity and greater entorhinal cortical thickness was mediated by reduced fasting insulin, indicating that regulation of metabolic risk factors may contribute to impact of aerobic exercise on the entorhinal cortex. Aerobic exercise may be helpful in counteracting metabolic side effects of antipsychotic medications and managing these side effects may be key to promoting entorhinal cortical plasticity in patients treated with second-generation antipsychotic drugs. |
| Databáze: | OpenAIRE |
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