An age-related decrease in factor V Leiden frequency among Polish subjects
| Autor: | Miłosz Parczewski, Mariusz Kaczmarczyk, Władysław Grzeszczak, Ewa Czerska, Janusz Gumprecht, A. Szybińska, Andrzej Ciechanowicz, Gail K. Adler, Beata Łoniewska, Małgorzata Mossakowska |
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| Předmět: |
Excessive Bleeding
Adult Male medicine.medical_specialty Aging Heterozygote Deep vein Longevity Biology Polymerase Chain Reaction White People Gene Frequency Internal medicine Genetics medicine Factor V Leiden Humans Allele Risk factor Alleles Aged 80 and over Infant Newborn Factor V Infant General Medicine medicine.disease Thrombosis Pulmonary embolism medicine.anatomical_structure Mutation Female Poland Complication Polymorphism Restriction Fragment Length |
| Zdroj: | Scopus-Elsevier |
| Popis: | Factor V Leiden (G1691AFV mutation) is a widely acknowledged risk factor of deep vein thrombosis, including pulmonary embolism as the most serious complication. However, its high prevalence of ∼5% in the Caucasian population might be related to an unknown evolutionary advantage. It might exert a beneficial effect on the carrier, e. g. protecting women from excessive bleeding during labour or allowing increased survival in severe sepsis or with other inflammatory diseases. The aim of our study was to verify or contradict the hypothesis of a favourable association between the A allele (A1691) and longevity in the Polish population. For this purpose, the G1691A mutation was analyzed by PCR-RFLP in 1016 Poles: 400 neonates (187 female and 312 male), 184 healthy adults (129 female and 55 male), and 432 long-lived individuals (age ≥ 95 years: 343 women and 89 men). Frequencies of G1691A carriers and the A1691 allele in long-lived individuals (0.2% and 0.1%, respectively) were significantly lower than in neonates (4.2% and 2.2%, respectively) and adults (3.3% and 1.6%). The frequency of the G1691A factor V Leiden mutation decreased with age, which indicates a shorter survival time among A1691 allele carriers in the Polish population. |
| Databáze: | OpenAIRE |
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