Accumbal dopamine D2 receptors are important for sensorimotor gating in C3H mice
| Autor: | Peter K. D. Pilz, Claudia F. Plappert, Markus Fendt, Daniela Mohr |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Reflex
Startle Startle response Quinpirole Time Factors Gating Nucleus accumbens Nucleus Accumbens Dihydrexidine Mice Dopamine Dopamine receptor D2 Basal ganglia Reaction Time Animals Medicine Prepulse inhibition Mice Inbred C3H Dose-Response Relationship Drug medicine.diagnostic_test Receptors Dopamine D2 business.industry General Neuroscience Neural Inhibition Phenanthridines Acoustic Stimulation Dopamine Agonists Female business Neuroscience Locomotion medicine.drug |
| Zdroj: | NeuroReport. 18:1493-1497 |
| ISSN: | 0959-4965 |
| Popis: | One operational measure of sensorimotor gating that is deficient in many psychiatric disorders is prepulse inhibition (PPI) of the startle response. To investigate the role of dopamine D1 and D2 receptors within the nucleus accumbens (NAC) in sensorimotor gating in mice, we infused dopamine D1 and D2 receptor agonists (dihydrexidine and quinpirole respectively) directly into the NAC and measured the effects on PPI and on prepulse facilitation. Quinpirole infusions increased PPI and attenuated prepulse facilitation, whereas dihydrexidine had no effects. These results stand in contrast to data after systemic injections in mice and rats and intra-accumbal infusions in rats, suggesting that the role of dopamine D2 receptors within the NAC in mice differs from their role in rats. |
| Databáze: | OpenAIRE |
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