[Biochemical and immunological markers of autoimmune thyroiditis]
| Autor: | L. I. Sattarova, O. A. Kravtsova, G. R. Vagapova, E. N. Chuhlovina, E. M. Biktagirova, Z. I. Abramova, Y. V. Skibo |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Programmed cell death endocrine system diseases Clinical Biochemistry Thyroid Gland Apoptosis Biochemistry General Biochemistry Genetics and Molecular Biology Receptors Tumor Necrosis Factor Autoimmune thyroiditis Annexin Internal medicine Medicine Humans Annexin A5 Autoantibodies biology business.industry Tumor Necrosis Factor-alpha Thyroid Autoantibody Thyroiditis Autoimmune General Medicine DNA Middle Aged medicine.disease Endocrinology medicine.anatomical_structure Healthy individuals Case-Control Studies Immunology biology.protein Molecular Medicine Female Antibody business hormones hormone substitutes and hormone antagonists Biomarkers |
| Zdroj: | Biomeditsinskaia khimiia. 62(4) |
| ISSN: | 2310-6972 |
| Popis: | Correlations between biochemical and immunological markers of programmed cell death (apoptosis), and the functional state of the thyroid gland (hyperthyroidism, euthyroidism, hypothyroidism) have been investigated in autoimmune thyroiditis (AT) (also known as chronic autoimmune thyroiditis). Annexin V, TRAIL and TNF-a, as well as DNA-hydrolyzing antibodies were used as the main markers. Increased levels of TRAIL were found in the serum of AT patients (hyperthyroidismhypothyroidismeuthyroidism) compared with healthy individuals. The highest frequency of antibodies to denatured DNA (Abs-dDNA) had the highest frequency in AT patients (97%) compared with healthy controls. Among these patients, 75% had hyperthyroidism, 85% had hypothyroidism, and 84.7% had euthyroidism. Abs hydrolyzing activity demonstrated correlation dependence with symptoms of the thyroid dysfunction.Izuchena korreliatsionnaia zavisimost' mezhdu biokhimicheskimi i immunologicheskimi markerami programmiruemoĭ kletochnoĭ gibeli (apoptoza) i funktsional'nym sostoianiem shchitovidnoĭ zhelezy (giper, éu,- gipotireoz) pri khronicheskom limfotsitarnom tireoidite (KhLT). V kachestve osnovnykh markerov byli vybrany anneksin V, TRAIL i TNF-a, a takzhe DNK-gidrolizuiushchie antitela (AT). Ustanovleno povyshenie urovnia TRAIL v syvorotke krovi u bol'nykh KhLT (gipertireozgipotireozéutireoz) po sravneniiu so zdorovymi. Naibolee chasto vstrechaiutsia antitela k denaturirovannoĭ DNK (AT-dDNK) (u 97% bol'nykh KhLT) po sravneniiu s kontrolem. Iz nikh u 75% pri gipertireoze, 85% pri gipotireoze, 84,7% pri éutireoze. Aktivnost' AT s gidrolizuiushcheĭ aktivnost'iu obnaruzhivaet korreliatsionnuiu zavisimost' s iavleniiami disfunktsii shchitovidnoĭ zhelezy. |
| Databáze: | OpenAIRE |
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