Performance status and end-of-life care among adults with non-small cell lung cancer receiving immune checkpoint inhibitors
| Autor: | Areej El-Jawahri, Laura A. Petrillo, Justin F. Gainor, Sienna Durbin, Kerry L. Reynolds, Ryan D. Nipp, Joseph A. Greer, Morgan Rl Lichtenstein, Jennifer S. Temel |
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| Rok vydání: | 2019 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Lung Neoplasms Referral medicine.medical_treatment Logistic regression 03 medical and health sciences 0302 clinical medicine Antineoplastic Agents Immunological Internal medicine Carcinoma Non-Small-Cell Lung medicine Humans 030212 general & internal medicine Karnofsky Performance Status Lung cancer Immune Checkpoint Inhibitors Aged Retrospective Studies Aged 80 and over Terminal Care Performance status business.industry Proportional hazards model Hazard ratio Immunotherapy Odds ratio Middle Aged medicine.disease Prognosis Survival Analysis Logistic Models 030220 oncology & carcinogenesis Female business |
| Zdroj: | CancerReferences. 126(10) |
| ISSN: | 1097-0142 |
| Popis: | BACKGROUND Adults with impaired performance status (PS) often receive immune checkpoint inhibitors (ICIs) for advanced non-small cell lung cancer (NSCLC) despite limited efficacy data and unknown effects on end-of-life care. METHODS This was a retrospective, single-site study of 237 patients with advanced NSCLC who initiated ICI treatment from 2015 to 2017. Cox regression was used to compare the overall survival (OS) of patients who had impaired PS (≥2) at the start of ICI treatment with those who had PS 0 or 1 using Cox regression. Logistic regression was conducted to analyze the association between ICI use in the last 30 days of life and the use of end-of-life health care. RESULTS The patient mean age at ICI initiation was 67 years (range, 37-91 years), and 35.4% of patients had PS ≥2. Most patients (80.8%) received ICI as second-line or later therapy. The median OS was 4.5 months in patients with PS ≥2 and 14.3 months in those with PS 0 or 1 (hazard ratio, 2.5; P |
| Databáze: | OpenAIRE |
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