Clinical Outcomes of Patients with Vogt-Koyanagi-Harada Disease Over 12 Years at a Tertiary Center
| Autor: | Igor Kozak, Andres F. Lasave, Vishali Gupta, J. Fernando Arevalo, Hassan A Al Dhibi, Mosa Barakat Al Harbi, Abdulaziz Adel Al Rushood |
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| Rok vydání: | 2015 |
| Předmět: |
Vogt–Koyanagi–Harada disease
Adult Male medicine.medical_specialty Visual acuity genetic structures Adolescent Prednisolone Visual Acuity Glaucoma Administration Oral Tertiary Care Centers 03 medical and health sciences 0302 clinical medicine Prednisone Recurrence Chart review Ophthalmology medicine Immunology and Allergy Humans Fluorescein Angiography Child Antibiotics Antitubercular Glucocorticoids Aged Retrospective Studies 030203 arthritis & rheumatology business.industry Panuveitis Exudative retinal detachment Middle Aged Mycophenolic Acid medicine.disease eye diseases Treatment Outcome Acute Disease Chronic Disease 030221 ophthalmology & optometry Drug Therapy Combination Female sense organs medicine.symptom business Uveomeningoencephalitic Syndrome Uveitis Tomography Optical Coherence medicine.drug |
| Zdroj: | Ocular immunology and inflammation. 24(5) |
| ISSN: | 1744-5078 |
| Popis: | Purpose: To describe the clinical characteristics and treatment outcomes of Vogt–Koyanagi–Harada (VKH) disease over a 12-year period.Methods: A retrospective chart review was used to identify VKH patients, from January 1999 to December 2011.Results: In total, 154 patients (308 eyes) were diagnosed with VKH. The mean age at diagnosis was 33.8 ± 13 years. Mean baseline best-corrected visual acuity (BCVA) was 20/125; (0.8 ± 0.6 logMAR). Recurrent episodes occurred in 107 (54%) patients. Oral prednisone was administered in all patients. At the last visit, the mean BCVA was 20/50 (0.4 ± 0.7 logMAR). The most common complications post-treatment were: glaucoma [104 (33.8%) eyes] and cataract [84 (27.2%) eyes].Conclusions: In Saudi Arabia, VKH-related uveitis is predominant in young females. Bilateral panuveitis is the most common ocular manifestation and near 50% of eyes present with exudative retinal detachment. Oral prednisone was the primary treatment and the majority of eyes maintained 20/50 or bette... |
| Databáze: | OpenAIRE |
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