Systems biology of yeast cell death
| Autor: | Kwanjeera Wanichthanarak, Dina Petranovic, Eugenio Meza, Ana Joyce Munoz |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Programmed cell death
biology Systems Biology Systems biology Saccharomyces cerevisiae Apoptosis General Medicine biology.organism_classification Applied Microbiology and Biotechnology Microbiology Yeast Cell biology Multicellular organism biology.protein Humans Gene Regulatory Networks Fragmentation (cell biology) Caspase Signal Transduction |
| Zdroj: | FEMS Yeast Research. 12:249-265 |
| ISSN: | 1567-1356 |
| DOI: | 10.1111/j.1567-1364.2011.00781.x |
| Popis: | Programmed cell death (PCD) (including apoptosis) is an essential process, and many human diseases of high prevalence such as neurodegenerative diseases and cancer are associated with deregulations in the cell death pathways. Yeast Saccharomyces cerevisiae, a unicellular eukaryotic organism, shares with multicellular organisms (including humans) key components and regulators of the PCD machinery. In this article, we review the current state of knowledge about cell death networks, including the modeling approaches and experimental strategies commonly used to study yeast cell death. We argue that the systems biology approach will bring valuable contributions to our understanding of regulations and mechanisms of the complex cell death pathways. |
| Databáze: | OpenAIRE |
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