Endocrinology: Induction of pre-ovulatory gonadotrophin surge with gonadotrophin-releasing hormone agonist compared to pre-ovulatory injection of human chorionic gonadotrophins for ovulation induction in intrauterine insemination treatment cycles
| Autor: | Eliezer Shalev, Moshe Ben-Ami, M. Matilsky, Yoel Geslevich |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
endocrine system
medicine.medical_specialty medicine.drug_class media_common.quotation_subject medicine.medical_treatment Twins Ovarian hyperstimulation syndrome Chorionic Gonadotropin Andrology Ovarian Hyperstimulation Syndrome Follicle-stimulating hormone Ovulation Induction Pregnancy Internal medicine Humans Medicine Ovulation Progesterone reproductive and urinary physiology Insemination Artificial Homologous media_common Unexplained infertility Gynecology Triptorelin Pamoate Estradiol business.industry Rehabilitation Obstetrics and Gynecology Luteinizing Hormone medicine.disease Triptorelin Abortion Spontaneous Endocrinology Reproductive Medicine Female Ovulation induction Follicle Stimulating Hormone Gonadotropin business Luteinizing hormone Infertility Female medicine.drug |
| Zdroj: | Human Reproduction. 10:2244-2247 |
| ISSN: | 1460-2350 0268-1161 |
| DOI: | 10.1093/oxfordjournals.humrep.a136277 |
| Popis: | The clinical outcome of intrauterine insemination (IUI) treatment cycles employing a gonadotrophin-releasing hormone agonist [GnRHa, triptorelin (Decapeptyl)] or human chorionic gonadotrophin (HCG) for ovulation induction was compared. A group of 48 patients presenting with amenorrhoea, oligomenorrhoea or unexplained infertility were all treated with human menopausal gonadotrophins (HMG) from day 5 of the cycle, on an individualized schedule. They were then randomly divided into two groups to receive either a single s.c. injection of 0.1 mg triptorelin or a single i.m. injection of 10,000 IU HCG after follicular maturation. IUI was performed approximately 24 and 48 h following the injection. A transitory increase in serum luteinizing hormone and follicle stimulating hormone concentrations was achieved following injection of GnRHa. A total of 24 patients received 72 treatment cycles with GnRHa, producing 11 conceptions (15.3%) and two abortions (18.2%), resulting in a term pregnancy rate of 13.6%. There were four cases of grade 3-4 ovarian hyperstimulation syndrome (OHSS), two of which were conception cycles. In all, 24 patients underwent 68 cycles treated with HCG, producing 18 conceptions (26.5%) and six abortions (33.3%), resulting in a term pregnancy rate of 19.0%. There were eight cycles of grade 3-4 OHSS, two of which were conception cycles. These results show that an s.c. injection of a relatively low dose of GnRHa can be as effective as HCG in producing pregnancy in IUI treatment cycles. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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