Relation of Coronary Microvascular Dysfunction in Hypertrophic Cardiomyopathy to Contractile Dysfunction Independent from Myocardial Injury
| Autor: | Adriaan A. Lammertsma, Jurriën M. ten Berg, Paul Knaapen, Tjeerd Germans, Iris K. Rüssel, Marco J.W. Götte, Folkert J. ten Cate, Albert C. van Rossum, Stefan A.J. Timmer, Mark Lubberink |
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| Přispěvatelé: | Cardiology, Radiology and nuclear medicine, ICaR - Heartfailure and pulmonary arterial hypertension |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Cardiovascular System Positron emission tomographic Coronary Circulation Internal medicine medicine Humans medicine.diagnostic_test business.industry Hypertrophic cardiomyopathy Magnetic resonance imaging Blood flow Cardiomyopathy Hypertrophic Middle Aged medicine.disease Coronary Vessels Magnetic Resonance Imaging Myocardial Contraction Adenosine Positron emission tomography Positron-Emission Tomography Microvessels Circulatory system Cardiology Female Cardiology and Cardiovascular Medicine business Perfusion medicine.drug |
| Zdroj: | American Journal of Cardiology, 107(10), 1522-1528. Elsevier Inc. Timmer, S A J, Germans, T, Gotte, M J W, Rüssel, I K, Lubberink, J M, ten Berg, J M, ten Cate, F J, Lammertsma, A A, Knaapen, P & van Rossum, A C 2011, ' Relation of Coronary Microvascular Dysfunction in Hypertrophic Cardiomyopathy to Contractile Dysfunction Independent from Myocardial Injury ', American Journal of Cardiology, vol. 107, no. 10, pp. 1522-1528 . https://doi.org/10.1016/j.amjcard.2011.01.029 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/j.amjcard.2011.01.029 |
| Popis: | We studied the spatial relations among hyperemic myocardial blood flow (hMBF), contractile function, and morphologic tissue alterations in 19 patients with hypertrophic cardiomyopathy (HC). All patients were studied with oxygen-15 water positron emission tomography during rest and adenosine administration to assess myocardial perfusion. Cardiovascular magnetic resonance was performed to derive delayed contrast-enhanced images and to calculate contractile function (E(cc)) with tissue tagging. Eleven healthy subjects underwent similar positron emission tomographic and cardiovascular magnetic resonance scanning protocols and served as a control group. In the HC group, hMBF averaged 2.46 +/- 0.91 ml/min/g and mean E(cc) was -14.7 +/- 3.4%, which were decreased compared to the control group (3.97 +/- 1.48 ml/min/g and -17.7 +/- 3.2%, respectively, p |
| Databáze: | OpenAIRE |
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