Anti-U11/U12 Antibodies as a Rare but Important Biomarker in Patients with Systemic Sclerosis: A Narrative Review

Autor: Marvin J. Fritzler, Chelsea Bentow, Lorenzo Beretta, Boaz Palterer, Janire Perurena-Prieto, Maria Teresa Sanz-Martínez, Alfredo Guillen-Del-Castillo, Ana Marín, Vicent Fonollosa-Pla, Eduardo Callejas-Moraga, Carmen Pilar Simeón-Aznar, Michael Mahler
Přispěvatelé: Institut Català de la Salut, [Fritzler MJ] Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. [Bentow C] Research and Development, Werfen, Autoimmunity Headquarters and Technology Center, San Diego, CA, USA. [Beretta L] Scleroderma Unit and (Referral) Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milan, Milano, Italy. [Palterer B] Department of Experimental and Clinical Medicine, University of Florence, Firenze, Italy. [Perurena-Prieto J, Sanz-Martínez MT, Marín A] Servei d’Immunologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Guillen-Del-Castillo A, Fonollosa-Pla V, Simeón-Aznar CP] Àrea de Malalties Autoimmunes Sistèmiques, Unitat d’Inflamació i Autoimmunitat, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus
Rok vydání: 2023
Předmět:
Amino Acids
Peptides
and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies::Antibodies
Antinuclear [CHEMICALS AND DRUGS]
Marcadors bioquímics
Skin and Connective Tissue Diseases::Connective Tissue Diseases::Scleroderma
Systemic [DISEASES]
aminoácidos
péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::autoanticuerpos::anticuerpos antinucleares [COMPUESTOS QUÍMICOS Y DROGAS]
Clinical Biochemistry
Other subheadings::/diagnosis [Other subheadings]
Otros calificadores::/diagnóstico [Otros calificadores]
Factors antinuclears
Biological Factors::Biomarkers [CHEMICALS AND DRUGS]
enfermedades de la piel y tejido conjuntivo::enfermedades del tejido conjuntivo::esclerodermia sistémica [ENFERMEDADES]
factores biológicos::biomarcadores [COMPUESTOS QUÍMICOS Y DROGAS]
Esclerosi sistemàtica progressiva - Diagnòstic
Zdroj: Scientia
ISSN: 2075-4418
DOI: 10.3390/diagnostics13071257
Popis: Autoantibodies; Interstitial lung disease; Systemic sclerosis Autoanticuerpos; Enfermedad pulmonar intersticial; Esclerosis sistémica Autoanticossos; Malaltia pulmonar intersticial; Esclerosi sistèmica Anti-nuclear (ANA) are present in approximately 90% of systemic sclerosis (SSc) patients and are key biomarkers in supporting the diagnosis and determining the prognosis of this disease. In addition to the classification criteria autoantibodies for SSc [i.e., anti-centromere, anti-topoisomerase I (Scl-70), anti-RNA polymerase III], other autoantibodies have been associated with important SSc phenotypes. Among them, anti-U11/U12 ribonucleoprotein (RNP) antibodies, also known as anti-RNPC-3, were first reported in a patient with SSc, but very little is known about their association and clinical utility. The U11/U12 RNP macromolecular complex consists of several proteins involved in alternative mRNA splicing. More recent studies demonstrated associations of anti-anti-U11/U12 antibodies with SSc and severe pulmonary fibrosis as well as with moderate to severe gastrointestinal dysmotility. Lastly, anti-U11/U12 autoantibodies have been strongly associated with malignancy in SSc patients. Here, we aimed to summarize the knowledge of anti-U11/U12/RNPC-3 antibodies in SSc, including their seroclinical associations in a narrative literature review.
Databáze: OpenAIRE
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