Validation of Outcome Instruments for Pediatric Postthrombotic Syndrome: Introducing the Peds-VEINES-QOL, a New Health-Related Quality of Life Instrument
| Autor: | Neil A. Goldenberg, Rhonda Knapp-Clevenger, Marilyn J. Manco-Johnson, Lillian Sung, Julie Smith, Beth Boulden Warren, Dianne Thornhill, Susan R. Kahn, Leonardo R. Brandão |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Intraclass correlation Deep vein Pain 030204 cardiovascular system & hematology Severity of Illness Index Postthrombotic Syndrome Young Adult 03 medical and health sciences 0302 clinical medicine Cronbach's alpha Quality of life Predictive Value of Tests Surveys and Questionnaires medicine Humans Child Stroke Pain Measurement Health related quality of life business.industry Postthrombotic syndrome Age Factors Infant Reproducibility of Results Venous Thromboembolism Hematology medicine.disease humanities medicine.anatomical_structure Convergent validity Case-Control Studies Child Preschool North America Quality of Life Physical therapy Female business 030215 immunology |
| Zdroj: | Thrombosis and Haemostasis. 121:1367-1375 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1055/s-0041-1725199 |
| Popis: | Background There is need for validated outcome measures for postthrombotic syndrome (PTS) following pediatric venous thromboembolism (VTE), with a focus on quality of life (QoL). Aims This article assesses reliability and validity of two PTS and two QoL scales for children following lower extremity VTE. Methods Pediatric patients following lower extremity VTE were recruited from three thrombosis clinics. The Manco–Johnson (MJ) and the modified Villalta (MV) PTS scales were compared with each other and with the generic pediatric health-related QoL, PedsQL, and a newly developed pediatric venous-specific QoL, the Peds-VEINES-QOL. Results Eighty children following VTE and 60 healthy control children were enrolled. Internal consistency measured by Cronbach's α was high for the two QoL scales, and moderate for the two PTS scales. Inter-rater reliability using intraclass correlation coefficients was moderate to high for the MJ, MV, and Peds-VEINES-QOL, and moderate for the PedsQL. Evidence of high internal consistency by Cronbach's α coefficients, and moderate to high interitem correlations support the premise that a single construct was measured by each instrument. Correlations between the four instruments indicate convergent validity. Conclusion The MJ and MV scales detect similar outcomes in children following VTE. As used, the MJ is slightly more sensitive to QoL because a positive diagnosis requires pain which is the leading factor in reduced QoL following deep vein thrombosis. When using the MV, a requirement for pain or abnormal use to diagnose PTS would make the MV a better predictor of QoL. |
| Databáze: | OpenAIRE |
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