Long-term Effect of Clofibrate on Albumin Turnover and Distribution in Man
| Autor: | H. Briem, T. V. Gudmundsson, T. Helgason |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent Albumins Internal medicine Internal Medicine medicine Humans Distribution (pharmacology) Term effect Clofibrate Serum Albumin Radio-Iodinated Serum Albumin Catabolism business.industry Significant difference Albumin Metabolism Middle Aged Control subjects Endocrinology Biochemistry Female business medicine.drug |
| Zdroj: | Acta Medica Scandinavica. 203:205-210 |
| ISSN: | 0001-6101 |
| Popis: | The long-term effect of clofibrate (at least 6 months' treatment) on albumin metabolism was investigated in 7 subjects and the results were compared with those from 15 control subjects. Human albumin labelled with 131I was used as a tracer. A significant difference between the groups was found in the following parameters: The clofibrate-treated group had a prolonged rapid component (t1 1/2) of the disappearance curve (p less than 0.05), relatively increased albumin in the extravascular space (i.e. decreased distribution ratio, p less than 0.01) and increased extravascular albumin space when corrected for body size by calculating it as per cent of the extravascular bromide space (p less than 0.01). There was no significant difference between the groups in albumin synthesis, fractional catabolic rate or the slow component (t2 1/2) of the disappearance curve. The results suggest that long-term treatment with clofibrate causes changes in the intercellular matrix. |
| Databáze: | OpenAIRE |
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