Hyperhomocysteinemia: an instigating factor for periodontal disease
| Autor: | Akash K. George, Dragana Stanisic, Irina A. Smolenkova, Mahavir Singh, Suresh C. Tyagi |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Periodontium 0301 basic medicine medicine.medical_specialty Hyperhomocysteinemia Homocysteine Physiology Cystathionine beta-Synthase Mice Transgenic Bone remodeling Proinflammatory cytokine Mice 03 medical and health sciences chemistry.chemical_compound Folic Acid 0302 clinical medicine Physiology (medical) Internal medicine Animals Humans Medicine Periodontal fiber Periodontitis Dental alveolus Pharmacology biology business.industry 030206 dentistry General Medicine medicine.disease Cystathionine beta synthase Disease Models Animal Oxidative Stress 030104 developmental biology Endocrinology chemistry biology.protein business |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 99:115-123 |
| ISSN: | 1205-7541 0008-4212 |
| DOI: | 10.1139/cjpp-2020-0224 |
| Popis: | Hyperhomocysteinemia (HHcy) affects bone remodeling, since a destructive process in cortical alveolar bone has been linked to it; however, the mechanism remains at large. HHcy increases proinflammatory cytokines viz. TNF-α, IL-1b, IL-6, and IL-8 that leads to a cascade that negatively impacts methionine metabolism and homocysteine cycling. Further, chronic inflammation decreases vitamins B12, B6, and folic acid that are required for methionine homocysteine homeostasis. This study aims to investigate a HHcy mouse model (cystathionine β-synthase deficient, CBS+/–) for studying the potential pathophysiological changes, if any, in the periodontium (gingiva, periodontal ligament, cement, and alveolar bone). We compared the periodontium side-by-side in the CBS+/– model with that of the wild-type (C57BL/6J) mice. Histology and histomorphometry of the mandibular bone along with gene expression analyses were carried out. Also, proangiogenic proteins and metalloproteinases were studied. To our knowledge, this research shows, for the first time, a direct connection between periodontal disease during CBS deficiency, thereby suggesting the existence of disease drivers during the hyperhomocysteinemic condition. Our findings offer opportunities to develop diagnostics/therapeutics for people who suffer from chronic metabolic disorders like HHcy. |
| Databáze: | OpenAIRE |
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