Mathematical modelling of growth of Escherichia coli at subinhibitory levels of chloramphenicol or tetracyclines
| Autor: | Flandrois, Jean-Pierre, Comby, S., Flandrois, J.P., Carret, G., Pichat, C. |
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| Přispěvatelé: | Bioinformatique, phylogénie et génomique évolutive (BPGE), Département PEGASE [LBBE] (PEGASE), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL) |
| Rok vydání: | 1989 |
| Předmět: |
Tetracycline
medicine.drug_class Antibiotics Biology medicine.disease_cause [SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics Phylogenetics and taxonomy Microbiology Models Biological 03 medical and health sciences [SDV.EE.ECO]Life Sciences [q-bio]/Ecology environment/Ecosystems medicine Escherichia coli Molecular Biology ComputingMilieux_MISCELLANEOUS 030304 developmental biology Doxycycline 0303 health sciences 030306 microbiology Chloramphenicol [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] General Medicine Ribosomal RNA Models Theoretical [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology Kinetics Biochemistry Tetracyclines Intracellular medicine.drug |
| Zdroj: | Research in Microbiology Research in Microbiology, Elsevier, 1989, 140 (3), pp.243-254. ⟨10.1016/0923-2508(89)90079-X⟩ Research in Microbiology, 1989, 140 (3), pp.243-254. ⟨10.1016/0923-2508(89)90079-X⟩ |
| ISSN: | 0923-2508 |
| DOI: | 10.1016/0923-2508(89)90079-X⟩ |
| Popis: | A mathematical model is suggested to describe the subinhibitory effects of chloramphenicol upon growth of Escherichia coli . It represents a generalization of Monod's equation. Our model was constructed entirely on the basis of biochemical factors, such as the reversibility of the interaction between the drug and its ribosomal target or intracellular uptake. The subinhibitory effects of chloramphenicol were satisfactorily described by this law within the range of 0.4–2.4 μg/ml. After simplifying the equation, this model was extrapolated to provide an accurate description of the mode of action of other bacteriostatic antibiotics which also inhibit the 50-S ribosomal subunit (tetracycline and doxycycline). The expanded model seems to accurately typify the effect of these antibiotics, whereas bactericidal aminoglycosides follow a completely different growth law. |
| Databáze: | OpenAIRE |
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