Intraoperative functional MRI as a new approach to monitor deep brain stimulation in Parkinson's disease
| Autor: | Christoph Wedekind, Klaus Lackner, Mohammad Maarouf, Volker Sturm, Oliver Schulte, Volker Hesselmann, Barbara Krug, Ralf Girnus, Bettina Sorger, Jürgen Bunke, Kathrin Lasek |
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| Rok vydání: | 2003 |
| Předmět: |
Pathology
medicine.medical_specialty Deep brain stimulation Parkinson's disease medicine.medical_treatment Electric Stimulation Therapy behavioral disciplines and activities Stereotaxic Techniques Subthalamic Nucleus Basal ganglia medicine Humans Radiology Nuclear Medicine and imaging Aged Intraoperative Care Resting state fMRI medicine.diagnostic_test business.industry Brain Parkinson Disease General Medicine medicine.disease Functional magnetic resonance spectroscopy of the brain Magnetic Resonance Imaging Electrodes Implanted Subthalamic nucleus nervous system Stereotaxic technique Female Functional magnetic resonance imaging business |
| Zdroj: | European radiology. 14(4) |
| ISSN: | 0938-7994 |
| Popis: | This article deals with technical aspects of intraoperative functional magnetic resonance imaging (fMRI) for monitoring the effect of deep brain stimulation (DBS) in a patient with Parkinson's disease. Under motor activation, therapeutic high-frequency stimulation of the subthalamic nucleus was accompanied by an activation decrease in the contralateral primary sensorimotor cortex and the ipsilateral cerebellum. Furthermore, an activation increase in the contralateral basal ganglia and insula region were detected. These findings demonstrate that fMRI constitutes a promising clinical application for investigating brain activity changes induced by DBS. |
| Databáze: | OpenAIRE |
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