HRT and breast cancer risk: a clue for interpreting the available data
| Autor: | Nicoletta Biglia, L. Lesca, Carlo Campagnoli, Piero Sismondi, C. Cantamessa |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Mammary gland Physiology Breast Neoplasms Overweight Hormone replacement therapy (HRT) General Biochemistry Genetics and Molecular Biology Breast cancer Risk Factors Internal medicine Epidemiology medicine Humans Obesity Sex hormone binding globulin (SHBG) Risk factor business.industry Body Weight Estrogen Replacement Therapy Obstetrics and Gynecology medicine.disease Menopause Epidemiologic Studies Endocrinology medicine.anatomical_structure Progestins Body weight Insulin-like growth factor I (IGF-I) Estrogen Female medicine.symptom business Progestin |
| Zdroj: | Maturitas. 33:185-190 |
| ISSN: | 0378-5122 |
| DOI: | 10.1016/s0378-5122(99)00082-1 |
| Popis: | Epidemiological and biological data on HRT and breast cancer risk are reviewed. Some aspects deserve consideration. (1) The majority of epidemiological data have been gathered from populations where high estrogen doses (> or = 1.25 mg daily of conjugated estrogens) were used as first line therapy. (2) HRT does not increase the risk in overweight women, even in the series in which a risk increase (in longterm users) is found. This could be as a result of the fact that oral estrogens, through their metabolic and hepatocellular effects, reverse some biological features of obesity (e.g. increased insulin-like growth factor I activity and decreased sex hormone binding globulin level) which potentially increase breast cancer risk, so balancing the estrogen stimulation. (3) The progestin addition seems to increase the risk when the 19 nor-testosterone derivatives are used. These androgenic compounds contrast the metabolic and hepatocellular effects of oral estrogens. To sum up, the possibility does exist that even the longterm use of oral estrogens at the right ('low') dose, with the addition of a non-androgenic progestin, will be shown to be associated with a very limited breast cancer risk increase. |
| Databáze: | OpenAIRE |
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