Age — a significant independent factor of A1C levels. Evidence from the National Health and Nutrition Examination Survey 1999–2014

Autor: Sue-Wei Luu, Christopher L. Bray, Hong Liang, Jing He, Dong Wang, Yanning Wang
Rok vydání: 2020
Předmět:
Adult
Blood Glucose
Male
medicine.medical_specialty
Time Factors
Adolescent
endocrine system diseases
National Health and Nutrition Examination Survey
Anemia
Endocrinology
Diabetes and Metabolism
Age adjustment
030209 endocrinology & metabolism
Risk Assessment
Prediabetic State
Young Adult
03 medical and health sciences
chemistry.chemical_compound
Age Distribution
0302 clinical medicine
Risk Factors
Internal medicine
Diabetes mellitus
Diabetes Mellitus
Internal Medicine
medicine
Humans
030212 general & internal medicine
Prediabetes
Sex Distribution
Child
Aged
Glycated Hemoglobin
Creatinine
Nutrition and Dietetics
business.industry
Middle Aged
Nutrition Surveys
medicine.disease
United States
Cross-Sectional Studies
chemistry
Abnormal Liver Function Test
Female
Family Practice
business
Biomarkers
Kidney disease
Zdroj: Primary Care Diabetes. 14:420-424
ISSN: 1751-9918
Popis: The aim of our study is to examine the association between age and A1C levels in nondiabetic subjects and develop the age-adjusted A1C levels for screening and diagnosis of prediabetes and diabetes.Participants from National Health and Nutrition Examination Survey (NHANES) -1999-2014 with age over 12 years were examined. Individuals with previous diagnosed diabetes, baseline anemia, established hemoglobinopathies, known liver or chronic kidney disease, and abnormal liver function tests or creatinine levels were excluded. Total 16949 subjects consisting of 8651 female subjects and 8298 male subjects were included in the analyses. Linear regression and multivariate regression analyses were performed to assess the relationship between A1C levels and age. Age adjusted A1C levels were determined.Significant positive correlation between A1C and age was found in both female and male subjects in the fasting plasma glucose (FPG) interval between 4.4-7mmol/L (80-126mg/dL) (P0.0001). There was a linear correlation between A1C levels and age. Linear regression analysis suggested A1C levels rose by 0.009% (about 0.09mmol/mol) in female and by 0.008% (about 0.08mmol/mol) in male per year in subjects without abnormality in glucose homeostasis (p0.0001).Our study concluded that age is a significant independent factor of A1C levels.
Databáze: OpenAIRE
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