Synthetic Lethality of Retinoblastoma Mutant Cells in the Drosophila Eye by Mutation of a Novel Peptidyl Prolyl Isomerase Gene
| Autor: | Gregory D. Plowman, Casey Kopczynski, Kim Lickteig, Lori Friedman, Christopher G. Winter, Matt B. Mahoney, Kellie Whittaker, Helen Francis-Lang, Marcia Belvin, Matthew V. Lorenzi, Ferhad Ahmad, Hanife Esengil, Annette L. Parks, Brent A. Rupnow, Monique Nicoll, Feng Chen, Lynn M. Young, Mariano Tabios, Kyle A. Edgar, Christopher C. Park, Amanda Norton, Laleh Shayesteh, Pamela M. Carroll |
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| Rok vydání: | 2005 |
| Předmět: |
Molecular Sequence Data
Synthetic lethality Investigations Biology Eye medicine.disease_cause Retinoblastoma Protein Genetics medicine Prolyl isomerase Animals Amino Acid Sequence Gene Peptidylprolyl isomerase Mutation Retinoblastoma Retinoblastoma protein Peptidylprolyl Isomerase medicine.disease biology.organism_classification Molecular biology Drosophila melanogaster biology.protein |
| Zdroj: | Genetics. 170:161-171 |
| ISSN: | 1943-2631 |
| DOI: | 10.1534/genetics.104.036343 |
| Popis: | Mutations that inactivate the retinoblastoma (Rb) pathway are common in human tumors. Such mutations promote tumor growth by deregulating the G1 cell cycle checkpoint. However, uncontrolled cell cycle progression can also produce new liabilities for cell survival. To uncover such liabilities in Rb mutant cells, we performed a clonal screen in the Drosophila eye to identify second-site mutations that eliminate Rbf− cells, but allow Rbf+ cells to survive. Here we report the identification of a mutation in a novel highly conserved peptidyl prolyl isomerase (PPIase) that selectively eliminates Rbf− cells from the Drosophila eye. |
| Databáze: | OpenAIRE |
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