Triazine–human serum albumin association: thermodynamic approach and sodium effect
| Autor: | Laurence Nicod, Jean Pierre Chaumont, Claire André, Eric Cavalli, Lhassane Ismaili, Alain Xicluna, J. Millet, Yves Claude Guillaume, Mireille Thomassin, Tong Thanh Truong |
|---|---|
| Přispěvatelé: | Cavalli, Eric, Fonctions et dysfonctions épithéliales - UFC (EA 4267) (FDE), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Ingénierie et biologie cellulaire et tissulaire (IBCT (ex IFR133)), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC) |
| Rok vydání: | 2002 |
| Předmět: |
[CHIM.ANAL] Chemical Sciences/Analytical chemistry
Sodium Clinical Biochemistry SODIUM CATION chemistry.chemical_element Biochemistry Analytical Chemistry Surface tension chemistry.chemical_compound [CHIM.ANAL]Chemical Sciences/Analytical chemistry medicine Humans Serum Albumin Triazine Chromatography Herbicides Triazines Chemistry Cell Biology General Medicine Human serum albumin body regions Solvent Carrier protein embryonic structures Molecular targets Thermodynamics medicine.drug |
| Zdroj: | Eric Cavalli Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, Elsevier, 2002, 780 (2), pp.467-74 |
| ISSN: | 1570-0232 1873-376X |
| DOI: | 10.1016/s1570-0232(02)00615-3 |
| Popis: | International audience; Human serum albumin (HSA) serves as a carrier protein to transport triazine herbicides to molecular targets. In this paper, a theoretical treatment was developed to describe the HSA-triazine herbicides association. A determination of the association constant, K, as well as the degree of complexation n(c) (the percent of complex guest) was carried out. Enthalpy-entropy compensation was also analyzed in relation to this mathematical model to confirm the herbicide complexation behavior with HSA. The role of the sodium cation (Na(+)) on this association was investigated. It was expected that the sodium ion would act on the herbicide-HSA association process by modifying the surface tension of the bulk solvent and increase the K and n(c) values. The results showed that for patients who suffer from Na(+) desequilibrium, the triazine-HSA binding would change and as well the toxicological effect of these herbicides. |
| Databáze: | OpenAIRE |
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