CSF analysis in patients with sporadic CJD and other transmissible spongiform encephalopathies
| Autor: | Anna Ladogana, Miguel Calero, N. Cuadrado-Corrales, Uta Heinemann, Eva Mitrova, C.M. van Duijn, Pascual Sánchez-Juan, Albert Saiz, Dana Slivarichova, Alison Green, Vittorio Mellina, Theodoros Sklaviadis, Katharina Stoeck, Jerzy Kulczycki, K Hess, Raquel Sánchez-Valle, Richard Knight, Inga Zerr |
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| Přispěvatelé: | Erasmus MC other, Epidemiology |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Heterozygote animal diseases Oligoclonal IgG Creutzfeldt-Jakob Syndrome Monocytes Prion Diseases 03 medical and health sciences Leukocyte Count 0302 clinical medicine Cerebrospinal fluid mental disorders Medicine Humans In patient Lymphocyte Count 030304 developmental biology Total protein Aged Aged 80 and over 0303 health sciences Sporadic CJD business.industry Homozygote Oligoclonal Bands Osmolar Concentration Genetic Variation Cerebrospinal Fluid Proteins Middle Aged Virology nervous system diseases 3. Good health Europe Neurology Csf analysis Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Neurology, 14(2), 121-124. Wiley-Blackwell Publishing Ltd |
| ISSN: | 1468-1331 1351-5101 |
| Popis: | Patients with suspected Creutzfeldt-Jakob disease (CJD) often have routine cerebrospinal fluid (CSF) analysis performed to exclude treatable inflammatory conditions; however, little information is available about the range of results obtained for CSF tests in patients with sporadic CJD and other transmissible spongiform encephalopathies (TSE). Data from 450 patients with sporadic CJD and 47 patients with other TSEs were collected as part of an EC-supported multinational study. Raised white cell counts of >5 cells/microl were found in three of 298 patients with sporadic CJD, with two cell counts of 7 cells/microl and one of 20 cells/microl. Total protein concentrations of >0.9 g/l were found in five of 438 patients with sporadic CJD, although none had a concentration of >1 g/l. CSF oligoclonal IgG was detected in eight of 182 sporadic CJD patients. Of the patients with other TSEs, six had elevated cell counts ranging from 6 to 14 cells/microl but none had total protein concentrations of >0.9 g/l and one patient had detectable oligoclonal IgG. None of the patients with sporadic CJD or other TSEs had abnormalities in all three tests. |
| Databáze: | OpenAIRE |
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