Cross-decoration of dendritic cells by non-inherited maternal antigen-containing extracellular vesicles: Potential mechanism for PD-L1-based tolerance in cord blood and organ transplantation

Autor:	Diego A. Lema, Ewa Jankowska-Gan, Ashita Nair, Sami B. Kanaan, Christopher J. Little, David P. Foley, Afsar Raza Naqvi, Jianxin Wang, Seungpyo Hong, J. Lee Nelson, David Al-Adra, William J. Burlingham, Jeremy A. Sullivan
Rok vydání:	2021
Předmět:	Transplantation Dendritic Cells Organ Transplantation Fetal Blood T-Lymphocytes Regulatory B7-H1 Antigen Extracellular Vesicles Mice Pregnancy Immune Tolerance Immunology and Allergy Animals Pharmacology (medical) Female Transplantation Tolerance Antigens
Zdroj:	American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 22(5)
ISSN:	1600-6143
Popis:	Exposure to non-inherited maternal antigens (NIMA) during the fetal period induces lifelong split tolerance to grafts expressing these allo-antigens. In adult mice, the production of extracellular vesicles (EVs) from maternal microchimeric cells causes cross-decoration (XD) of offspring dendritic cells (DC) with NIMA and upregulation of PD-L1, contributing to NIMA tolerance. To see how this may apply to humans, we tested NIMA acquisition by fetal DCS in human cord blood. The average percentage of NIMA-XD among total DCs was 2.6% for myeloid and 4.5% for Plasmacytoid DC. These cells showed higher PD-L1 expression than their non-XD counterparts (mDC: p = .0016; pDC: p = .024). We detected CD9
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65073b17ef81b499727af95114a73a0d https://pubmed.ncbi.nlm.nih.gov/35143105 Zobrazit plný text záznamu Plný text