Herpes simplex virus infections in children
| Autor: | Lawrence R. Stanberry, Beverly L. Connelly |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.drug_class
viruses Acyclovir HSL and HSV Disease medicine.disease_cause Polymerase Chain Reaction medicine Humans Encephalitis Viral Child Vaccines Synthetic medicine.diagnostic_test biology business.industry Viral culture Brain biopsy Herpes Simplex medicine.disease Herpes simplex virus Pediatrics Perinatology and Child Health Immunology biology.protein Antiviral drug Antibody business Encephalitis |
| Zdroj: | Current Opinion in Pediatrics. 7:19-23 |
| ISSN: | 1040-8703 |
| DOI: | 10.1097/00008480-199502000-00005 |
| Popis: | This paper focuses on the advances that have been made in our understanding of the pathogenesis, diagnosis, treatment, and prevention of herpes simplex virus (HSV) infections. Insights have been gained into the immune defense mechanisms that may be active in protecting the fetus from HSV infection. An animal model that closely mimics human neonatal HSV disease may permit exploration of novel interventional strategies. Brain biopsy for the diagnosis of HSV encephalitis has been supplanted by polymerase chain reaction detection of HSV DNA in the cerebrospinal fluid and, to a lesser extent, by detection of intrathecal HSV-specific antibodies. Prolonged immune activation within the nervous system following HSV encephalitis has been demonstrated and may implicate immune activation in the pathogenesis of HSV-induced neurologic damage. The continuing emergence of antiviral drug resistance further underscores the need for new strategies for treatment and prevention of HSV infections. |
| Databáze: | OpenAIRE |
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