Genetic variation in the promoter region of the TNF rs1800629 gene is not associated with adiposity index, but AA genotype is more likely to have low cellular membrane integrity
| Autor: | Marise Fagundes Silveira, Alfredo Maurício Batista de Paula, Geórgia das Graças Pena, Sérgio Henrique Sousa Santos, Renato Sobral Monteiro Junior, Tatiana Carvalho Reis Martins, Rosângela Ramos Veloso Silva, João Felício Rodrigues Neto, André Luiz Sena Guimarães, Ugo Borges Pinheiro |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Waist Tecido adiposo Population 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Overweight Biology 03 medical and health sciences 0302 clinical medicine Internal medicine Genotype Genetics medicine education Fator de necrose de tumor Genetics (clinical) Waist-to-height ratio education.field_of_study Polimorfismo (Genética) medicine.disease Obesity Genotype frequency Endocrinology Obesidade Population study medicine.symptom Antropometria |
| Zdroj: | Repositório Institucional da UFMG Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
| Popis: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Background: the complex pathophysiology of obesity includes low-grade chronic inflammation of white adipose tissue, an increase in plasma levels of pro-inflammatory cytokines as well as genetic factors, which have all emerged as important risk factors. Objective: evaluate the association between the TNFα-308G/A variant and sociodemographic, clinical and behavioral variables in an urban population using overall and central obesity as the measured outcome. Methods: a cross-sectional population-based study was conducted. Anthropometric measures and genotyping were assessed in 808 individuals. The associations were tested using the hierarchical theoretical model and multiple logistic regressions. Results: thirty-one percent of subjects were overweight while 19.4% were obese. No association was observed between genotype frequencies of TNFα-308G/A and either obesity or other variables of adiposity, including waist circumference, waist to height ratio, conicity index, and fat mass. However, age, gender, physical inactivity, and other comorbidities were associated with measures of excess adiposity in the hierarchical model. The phase angle of AA genotype was lower than GA and GG genotypes (p < 0.05). Conclusion: the rs1800629 SNP of the TNFA gene was not associated with the adiposity indicators evaluated in this based population study. However, AA genotype is more likely to have low cellular membrane integrity. |
| Databáze: | OpenAIRE |
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