Long-range inhibitory mechanisms in the visual system are impaired in migraine sufferers
| Autor: | Doreen Wagner, Gael E. Gordon, Velitchko Manahilov, Peter Storch |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Migraine without Aura medicine.medical_specialty Aura Migraine with Aura Audiology Inhibitory postsynaptic potential Membrane Potentials Contrast Sensitivity Young Adult medicine Humans Scotoma Dynamic noise Visual Cortex Neurons business.industry Blind spot General Medicine medicine.disease Afterimage Migraine Homogeneous Anesthesia Visual Perception Female Neurology (clinical) business Photic Stimulation |
| Zdroj: | Cephalalgia. 32:1071-1075 |
| ISSN: | 1468-2982 0333-1024 |
| DOI: | 10.1177/0333102412455712 |
| Popis: | Background: After viewing dynamic noise surrounding a homogeneous grey patch (artificial scotoma), observers perceive a prolonged twinkling-noise after-image within the unstimulated area. It has been suggested that noise-stimulated neurons induce a long-range inhibition in neurons within the artificial scotoma, which generates a rebound signal perceived as twinkling noise following noise termination. We used this paradigm to test whether migraineurs have enhanced excitability or weakened inhibition. Methods: Twinkling-noise duration was measured in 13 headache-free volunteers, 13 migraineurs with aura and 13 migraineurs without aura. Results: The durations of the after-image were significantly shorter for both migraine groups compared to controls. Discussion: Enhanced excitation of noise-activated neurons in migraineurs would produce stronger rebound activity and longer after-image durations, while weakened inhibitory mechanisms would diminish the rebound activity and shorten the after-image durations compared to control subjects. The results suggest that cortical inhibitory mechanisms might be impaired in migraineurs with and without aura. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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