Long-term exposure to outdoor air pollution and risk factors for cardiovascular disease within a cohort of older men in Perth
| Autor: | Osvaldo P. Almeida, Graeme J. Hankey, Mark J. Nieuwenhuijsen, Paul Norman, Lee Nedkoff, Stephen Vander Hoorn, Bert Brunekreef, Kevin Murray, Jane Heyworth, Bu B. Yeap, Leon Flicker |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Time Factors Epidemiology Health Toxicology and Mutagenesis Air pollution Social Sciences Blood Pressure Disease Cardiovascular Medicine medicine.disease_cause Biochemistry Vascular Medicine Cohort Studies chemistry.chemical_compound Medical Conditions Endocrinology Sociology Risk Factors Medicine and Health Sciences Medicine Immune Response medical risk factors Global and Planetary Change Schools Multidisciplinary Air pollutant concentrations Geography Confounding Confounding Factors Epidemiologic Pollution Lipids Cholesterol Cardiovascular Diseases Cohort Regression Analysis Environmental Monitoring Research Article Endocrine Disorders Science Immunology Cardiology Education Signs and Symptoms Air Pollution Environmental health Diabetes mellitus Confidence Intervals Diabetes Mellitus Humans Triglycerides Aged Inflammation Pollutant business.industry Cholesterol HDL Ecology and Environmental Sciences Public Health Environmental and Occupational Health Australia Biology and Life Sciences Environmental Exposure Cardiovascular Disease Risk medicine.disease Confidence interval Term (time) Blood pressure chemistry Metabolic Disorders Particulate Matter Clinical Medicine business |
| Zdroj: | PLoS ONE PLoS ONE, Vol 16, Iss 3, p e0248931 (2021) |
| ISSN: | 1932-6203 |
| Popis: | While there is clear evidence that high levels of pollution are associated with increased all-cause mortality and cardiovascular mortality and morbidity, the biological mechanisms that would explain this association are less understood. We examined the association between long-term exposure to air pollutants and risk factors associated with cardiovascular disease. Air pollutant concentrations were estimated at place of residence for cohort members in the Western Australian Centre for Health and Ageing Health in Men Study. Blood samples and blood pressure measures were taken for a cohort of 4249 men aged 70 years and above between 2001 and 2004. We examined the association between 1-year average pollutant concentrations with blood pressure, cholesterol, triglycerides, C-reactive protein, and total homocysteine. Linear regression analyses were carried out, with adjustment for confounding, as well as an assessment of potential effect modification. The four pollutants examined were fine particulate matter, black carbon (BC), nitrogen dioxide, and nitrogen oxides. We found that a 2.25 μg/m3 higher exposure to fine particulate matter was associated with a 1.1 percent lower high-density cholesterol (95% confidence interval: -2.4 to 0.1) and 4.0 percent higher serum triglycerides (95% confidence interval: 1.5 to 6.6). Effect modification of these associations by diabetes history was apparent. We found no evidence of an association between any of the remaining risk factors or biomarkers with measures of outdoor air pollution. These findings indicate that long-term PM2.5 exposure is associated with elevated serum triglycerides and decreased HDL cholesterol. This requires further investigation to determine the reasons for this association. |
| Databáze: | OpenAIRE |
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