Dynamics of endothelial progenitor cells in patients with advanced hepatocellular carcinoma

Autor:	Claudia Campani, Manuela Capone, Francesco Liotta, Umberto Arena, Valentina Adotti, Chiara Di Bonaventura, Sami Aburas, Stefano Colagrande, Linda Calistri, Francesco Annunziato, Fabio Marra
Rok vydání:	2022
Předmět:	Carcinoma Hepatocellular Hepatology Liver Neoplasms Gastroenterology Humans Antigens CD34 Sorafenib Flow Cytometry Biomarkers Endothelial Progenitor Cells
Zdroj:	Digestive and Liver Disease. 54:911-917
ISSN:	1590-8658
DOI:	10.1016/j.dld.2021.11.010
Popis:	Circulating endothelial progenitor cells (EPC) predict tumor vascularization and disease progression, but limited information is available on their dynamics in hepatocellular carcinoma (HCC) undergoing systemic treatment.We prospectively analyzed different populations of EPC in 16 patients with advanced HCC receiving sorafenib. Patients were studied before therapy (T0, n = 16) and after two (T2, n = 12) and eight weeks (T8, n = 8), using high-performance flow-cytometry. The tumor response at T8 was categorized as progressive disease (PD) or clinical benefit (CB, all other responses).At T0, higher levels of CD34In patients with advanced HCC, EPC are directly correlated with platelet count, suggesting a common activation of selected bone marrow pathways. Levels of a CD34
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6504cf6d1f5b14884824f561ebb86e4c https://doi.org/10.1016/j.dld.2021.11.010 Zobrazit plný text záznamu Full Text from ScienceDirect