Enhanced chemotaxis to gentamicin-resistant strains of Pseudomonas aeruginosa

Autor:	Harry P. Bassaris, Anastasius S. Dontas, Popi E. Lianou, Nicholas J. Legakis, J. Papavassiliou
Rok vydání:	1980
Předmět:	Pseudomonas aeruginosa medicine.drug_class Chemistry Neutrophils Antibiotics Virulence Chemotaxis Drug Resistance Microbial Drug resistance medicine.disease_cause Microbiology Chemotaxis Leukocyte Infectious Diseases medicine Immunology and Allergy Humans Gentamicin Gentamicins medicine.drug
Zdroj:	The Journal of infectious diseases. 141(4)
ISSN:	0022-1899
Popis:	The chemotactic response of human polymorphonuclear leukocytes (PMNLs) to gentamicin-sensitive and gentamicin-resistant strains of Pseudomonas aeruginosa was studied. Filtrates from the resistant strains markedly enhanced the chemotactic response of human PMNLs (leukotactic index [LI] = 40.4 micron), in contrast to the filtrates from the sensitive strains, which induced less migration of PMNLs (LI = 26.8 micron). This finding may explain previous observations that suggested that gentamicin-resistant strains of P. aeruginosa are less virulent than gentamicin-sensitive strains.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65040b0353ff0760d45a43563f0c1eaa https://pubmed.ncbi.nlm.nih.gov/6768811 Zobrazit plný text záznamu