Toxicity, analgesic and anti-inflammatory activities of tectorigenin
| Autor: | Nguyen Tien Dat, Pham Quoc Long, Do Thi Huyen, Do Thi Nguyet Que, Le Minh Ha |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Tectorigenin Analgesic effect medicine.drug_class Immunology Analgesic Subacute toxicity Pain Pharmacology Toxicology Anti-inflammatory Iridaceae Lethal Dose 50 Mice chemistry.chemical_compound Toxicity Tests Acute Animals Edema Immunology and Allergy Medicine Rats Wistar Medicine East Asian Traditional business.industry Anti-Inflammatory Agents Non-Steroidal Visceral pain General Medicine Isoflavones Rats Toxicity Tests Subacute chemistry Belamcanda chinensis Toxicity Female medicine.symptom business Rhizome |
| Zdroj: | Immunopharmacology and Immunotoxicology. 35:336-340 |
| ISSN: | 1532-2513 0892-3973 |
| Popis: | Belamcanda chinensis has been used in oriental medicine for the treatment of inflammatory diseases. Tectorigenin is a main compound in B. chinensis and possess inhibitory activity against inflammatory responses. Thus, the current study aimed at evaluating toxicity as well as analgesic and anti-inflammatory effects of tectorigenin in animal models.Tectorigenin was employed to evaluate acute and subacute toxicity. Acetic acid-induced writhing in mice was used for analgesic test. The anti-inflammatory activity was tested in carrageenan-induced paw edema.LD(50) of tectorigenin was 1.78 g/kg p.o. in mice and no toxic symptoms were observed at doses up to 300 mg/kg in a subacute toxicity test during 28-day treatment. Tectorigenin at doses of 50 and 100 mg/kg had an analgesic effect on acetic acid-induced acute visceral pain in mice. In inflammatory rat model, tectorigenin at 60 mg/kg significantly reduced carrageenan-induced edema.We demonstrated that tectorigenin is a safe and promising analgesic and anti-inflammatory agent. |
| Databáze: | OpenAIRE |
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