Cytotoxic steroidal saponins from Trillium kamtschaticum
| Autor: | Yong-Ai Si, Xu-Jie Qin, Wei Ni, Huan Yan, Yu Chen, Hai-Yang Liu, Hui Liu, Tong Shu, Yun-Heng Ji |
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| Rok vydání: | 2017 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization Stereochemistry Proton Magnetic Resonance Spectroscopy Clinical Biochemistry Pharmaceutical Science 01 natural sciences Biochemistry chemistry.chemical_compound Inhibitory Concentration 50 Drug Discovery Cytotoxic T cell Humans Carbon-13 Magnetic Resonance Spectroscopy Molecular Biology biology 010405 organic chemistry Liliaceae Organic Chemistry Saponins biology.organism_classification HCT116 Cells Trillium kamtschaticum 0104 chemical sciences 010404 medicinal & biomolecular chemistry Aglycone chemistry Trillium Molecular Medicine Steroids |
| Zdroj: | Bioorganicmedicinal chemistry letters. 27(11) |
| ISSN: | 1464-3405 |
| Popis: | Eight new steroidal saponins, trillikamtosides K-R (1-8), along with three known analogues, were isolated from the whole plants of Trillium kamtschaticum. Their structures were unambiguously established by interpretation of spectroscopic data (MS and NMR) and chemical methods. Compound 1 had a rare aglycone featuring a skeleton of 16-oxaandrost-5-en-3-ol-17-one, which was reported for the first time. The isolated saponins were tested for cytotoxicities against HCT116 cells, and trillikamtoside R (8) was found to show the most cytotoxic effect with an IC50 value of 4.92μM. |
| Databáze: | OpenAIRE |
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