Association between Angiotensin-Converting Enzyme Gene Polymorphism and Alzheimer’s Disease in a Chinese Population
| Autor: | Zhen-Xin Zhang, Ya-Ning Wu, Xiao-Qing Li, Qiu-Ming Qu, Jun-Wu Zhang, Deng Chen, Hua-Lu Zhao |
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| Rok vydání: | 2005 |
| Předmět: |
Male
China medicine.medical_specialty Cognitive Neuroscience Population Apolipoproteins E Asian People Gene Frequency Alzheimer Disease Risk Factors Polymorphism (computer science) Internal medicine Endopeptidases Renin Genotype medicine Humans Allele Risk factor education Allele frequency Aged DNA Primers Aged 80 and over education.field_of_study Polymorphism Genetic business.industry Middle Aged Genotype frequency Psychiatry and Mental health Endocrinology Population Surveillance Female Gene polymorphism Geriatrics and Gerontology business |
| Zdroj: | Dementia and Geriatric Cognitive Disorders. 20:52-56 |
| ISSN: | 1421-9824 1420-8008 |
| Popis: | Angiotensin-converting enzyme has shown altered activity in patients with neurological diseases. An insertion/deletion (I/D) polymorphism of the DCP1 gene encoding angiotensin-converting enzyme has been reported to be associated with the risk for Alzheimer’s disease (AD), but ambiguous results have also been presented. We conducted a case-control study in a sample composed of 192 sporadic AD patients and 195 age- and sex-matched controls from Chinese Han population in Beijing and Xi’an districts to investigate the possible effect of the polymorphism. Our data revealed no association between the DCP1 polymorphism and AD risk in the total sample. There was no significant difference in the DCP1 allele or genotype frequencies between cases and controls when stratified by gender and APOE ε4 status. However, the D allele and D/D genotype were more frequent among AD patients between 66 and 70 years compared with controls (D allele: OR = 2.8, 95% CI = 1.5–5.2, p = 0.001; D/D genotype: OR = 5.9, 95% CI = 1.7–19.9, p = 0.002). Our results provided new proof that the DCP1 D allele was a probable risk factor for late-onset AD. Its role was independent and was limited to the population at a certain age. |
| Databáze: | OpenAIRE |
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