Cutaneous and subcutaneous metastasis of appendicular osteosarcoma in dogs: 20 cases

Autor: Timothy Vernier, Travis Laver, MacKenzie Pellin, Bernard Séguin, Camille C. Hanot, Cyril Parachini-Winter, Kaitlin M. Curran
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
Lung Neoplasms
Skin Neoplasms
040301 veterinary sciences
medicine.medical_treatment
Population
Bone Neoplasms
Standard Article
Kaplan-Meier Estimate
030204 cardiovascular system & hematology
primary bone tumor
Metastasis
0403 veterinary science
03 medical and health sciences
0302 clinical medicine
Dogs
stage III osteosarcoma
Medicine
Animals
Dog Diseases
education
prognostic factor
Survival analysis
Retrospective Studies
education.field_of_study
Chemotherapy
Osteosarcoma
lcsh:Veterinary medicine
General Veterinary
business.industry
Medical record
Bone metastasis
skin metastasis
Extremities
04 agricultural and veterinary sciences
medicine.disease
Prognosis
Survival Analysis
Standard Articles
medicine.anatomical_structure
oncology
lcsh:SF600-1100
Female
Radiology
SMALL ANIMAL
business
Subcutaneous tissue
Zdroj: Journal of Veterinary Internal Medicine, Vol 33, Iss 5, Pp 2200-2208 (2019)
Journal of Veterinary Internal Medicine
ISSN: 0891-6640
1939-1676
Popis: Background Metastasis of appendicular osteosarcoma is most common to the lungs and is generally considered a terminal event in dogs. Behavior and prognosis associated with cutaneous or subcutaneous metastases (CSM) is poorly defined. Objective Describe the population and gather prognostic information regarding appendicular osteosarcoma with CSM in dogs. Animals Twenty dogs with appendicular osteosarcoma and CSM. Methods Retrospective case series. Medical records were searched to identify dogs diagnosed with appendicular osteosarcoma that developed CSM. Demographic data, order of metastatic events, and CSM clinical features were evaluated. Kaplan‐Meier survival curves were constructed and log‐rank tests were used to compare survival between groups of dogs. Results In 19 dogs (95%), CSM was an incidental finding. Seventeen dogs (85%) developed pulmonary metastasis, and 1 dog (5%) developed bone metastasis. No other metastatic sites were detected before euthanasia. The median CSM‐free interval and CSM survival time were 160 days (range: 0‐542 days) and 55 days (range: 5‐336 days), respectively. The median CSM survival time was significantly longer for dogs treated with surgery and chemotherapy (94 days) or chemotherapy only (64 days) than for dogs that did not receive these treatments (11 days) (P = .002 and P = .03, respectively). No other factors were associated with survival after diagnosis of CSM. Conclusion and Clinical Importance The skin or subcutaneous tissue can be the first osteosarcoma metastatic site detected. After CSM diagnosis, the prognosis is grave with median survival
Databáze: OpenAIRE
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