Fibroblast growth factor-23 as a predictor biomarker of acute kidney injury after cardiac surgery
| Autor: | Hossam A. Sayed, Mahmoud M Elnokeety, Amr M. Shaker, Eman El. Mohamed, Tarek Ramzy, Hussein H. Samir |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty 030232 urology & nephrology Urology lcsh:Medicine urologic and male genital diseases law.invention 03 medical and health sciences chemistry.chemical_compound Postoperative Complications 0302 clinical medicine law medicine Cardiopulmonary bypass Humans Prospective Studies Cardiac Surgical Procedures Creatinine Univariate analysis urogenital system business.industry lcsh:R Area under the curve Acute kidney injury General Medicine Acute Kidney Injury Middle Aged medicine.disease female genital diseases and pregnancy complications Cardiac surgery Fibroblast Growth Factors Fibroblast Growth Factor-23 030104 developmental biology chemistry Biomarker (medicine) Female business Biomarkers Kidney disease |
| Zdroj: | Saudi Journal of Kidney Diseases and Transplantation, Vol 29, Iss 3, Pp 531-539 (2018) |
| ISSN: | 1319-2442 |
| DOI: | 10.4103/1319-2442.235180 |
| Popis: | Renal ischemia/reperfusion injury is a major cause of acute kidney injury (AKI). The lack of early biomarkers for predicting AKI has hampered our ability to initiate preventive and therapeutic measures in an opportune way. Fibroblast growth factor 23 (FGF-23) is elevated in chronic kidney disease, but data on FGF-23 in humans with AKI are limited. Herein, we tested whether FGF-23 levels rise early in the course of AKI following cardiac surgery. We prospectively evaluated eighty adult patients who underwent cardiac surgery. Patients were divided into two groups (AKI and non-AKI group) on the basis of whether they developed postoperative AKI within 24 h after surgery. Plasma FGF-23 levels were measured before surgery and 24 h after surgery. The primary outcome was AKI diagnosed using the AKI Network criteria. Forty-five patients (56.2.5%) developed AKI after surgery. Plasma FGF-23 increased significantly from a mean of 26.8 ± 2.47 ng/mL at baseline to 341.7 ± 38.1 ng/mL 24 h after cardiopulmonary bypass. Univariate analysis showed a significant correlation between AKI and the following: percent change in plasma FGF-23, postoperative serum level of creatinine, FGF-23, and neutrophil gelatinase-associated lipocalin. Receiver operating characteristic curve analysis revealed that, for percent change in plasma FGF-23 concentrations at 24 h, the area under the curve was 0.9, sensitivity was 100%, and specificity was 97.1%. Plasma FGF-23 percent change is more valid compared with FGF-23 before or after procedure in the prediction of AKI and represents a novel and highly predictive early biomarker for AKI after cardiac surgery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|