Aerobic bacteria associated with chronic suppurative otitis media in Angola

Autor: Erika Matuschek, Maria Paul, Matuba Filipe, Tuula Pelkonen, Sven Hammerschmidt, Kristian Riesbeck, John Thegerström, Åke Reimer, Fabian Uddén
Přispěvatelé: Children's Hospital, University of Helsinki, Clinicum, HUS Children and Adolescents
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Aerobic bacteria
Chronic Suppurative Otitis Media
Antibiotics
CHILDREN
medicine.disease_cause
Otitis Media
Suppurative
0302 clinical medicine
3123 Gynaecology and paediatrics
Nasopharynx
030223 otorhinolaryngology
Child
lcsh:Public aspects of medicine
RESISTANT STAPHYLOCOCCUS-AUREUS
General Medicine
Bacterial Infections
Middle Aged
3. Good health
PREVALENCE
Bacteria
Aerobic
Infectious Diseases
medicine.anatomical_structure
Staphylococcus aureus
Child
Preschool
Pseudomonas aeruginosa
Middle ear
Female
Infection
Research Article
Adult
Adolescent
medicine.drug_class
Enterobacteria
030106 microbiology
Perforation (oil well)
Ear
Middle
PROFILE
Microbiology
lcsh:Infectious and parasitic diseases
03 medical and health sciences
Young Adult
Antibiotic resistance
medicine
otorhinolaryngologic diseases
Humans
lcsh:RC109-216
NIGERIA
Otitis media
Aged
business.industry
Public Health
Environmental and Occupational Health
Infant
Newborn
Infant
LUANDA
lcsh:RA1-1270
Chronic suppurative otitis media
Proteus
Angola
3121 General medicine
internal medicine and other clinical medicine
Chronic Disease
business
EARDROPS
Zdroj: Infectious Diseases of Poverty
Infectious Diseases of Poverty, Vol 7, Iss 1, Pp 1-10 (2018)
Popis: Background Chronic suppurative otitis media (CSOM) is an important cause of hearing loss in children and constitutes a serious health problem globally with a strong association to resource-limited living conditions. Topical antibiotics combined with aural toilet is the first-hand treatment for CSOM but antimicrobial resistance and limited availability to antibiotics are obstacles in some areas. The goal of this study was to define aerobic pathogens associated with CSOM in Angola with the overall aim to provide a background for local treatment recommendations. Methods Samples from ear discharge and the nasopharynx were collected and cultured from 152 patients with ear discharge and perforation of the tympanic membrane. Identification of bacterial species was performed with matrix-assisted laser desorption/ionization-time of flight mass spectrometry and pneumococci were serotyped using multiplex polymerase chain reactions. Antimicrobial susceptibility testing was done according to EUCAST. Results One hundred eighty-four samples from ear discharge and 151 nasopharyngeal swabs were collected and yielded 534 and 289 individual isolates, respectively. In all patients, correspondence rate of isolates from 2 ears in patients with bilateral disease was 27.3% and 9.3% comparing isolates from the nasopharynx and ear discharge, respectively. Proteus spp. (14.7%), Pseudomonas aeruginosa (13.2%) and Enterococcus spp. (8.8%) were dominating pathogens isolated from ear discharge. A large part of the remaining species belonged to Enterobacteriaceae (23.5%). Pneumococci and Staphylococcus aureus were detected in approximately 10% of nasopharyngeal samples. Resistance rates to quinolones exceeded 10% among Enterobacteriaceae and was 30.8% in S. aureus, whereas 6.3% of P. aeruginosa were resistant. Conclusions The infection of the middle ear in CSOM is highly polymicrobial, and isolates found in nasopharynx do not correspond well with those found in ear discharge. Pathogens associated with CSOM in Angola are dominated by gram-negatives including Enterobacteriaceae and P. aeruginosa, while gram-positive enterococci also are common. Based on the results of antimicrobial susceptibility testing topical quinolones would be the preferred antibiotic therapy of CSOM in Angola. Topical antiseptics such as aluminium acetate, acetic acid or boric acid, however, may be more feasible options due to a possibly emerging antimicrobial resistance. Electronic supplementary material The online version of this article (10.1186/s40249-018-0422-7) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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