Modulation of cytokine and cytokine receptor/antagonist by treatment with doxycycline and tetracycline in patients with dengue fever
| Autor: | I. Vado-Solis, T. M. Fredeking, C. Perez-Osorio, J. E. Z. Castro |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Adult Male Article Subject Adolescent medicine.drug_class medicine.medical_treatment Immunology Interleukin-1beta Enzyme-Linked Immunosorbent Assay Dengue virus medicine.disease_cause Severity of Illness Index Receptors Tumor Necrosis Factor Dengue fever Young Adult medicine Immunology and Allergy Humans Severe Dengue Interleukin 6 Child Doxycycline biology business.industry Interleukin-6 Tumor Necrosis Factor-alpha Antagonist General Medicine Middle Aged Tetracycline medicine.disease Receptor antagonist Interleukin 1 Receptor Antagonist Protein Cytokine Treatment Outcome biology.protein Clinical Study Female lcsh:RC581-607 business Cytokine receptor medicine.drug |
| Zdroj: | Clinical and Developmental Immunology Clinical and Developmental Immunology, Vol 2011 (2011) |
| ISSN: | 1740-2530 |
| Popis: | Dengue virus infection can lead to dengue fever (DF) or dengue hemorrhagic fever (DHF). Disease severity has been linked to an increase in various cytokine levels. In this study, we evaluated the effectiveness of doxycycline and tetracycline to modulate serum levels of IL-6, IL-1B, and TNF and cytokine receptor/receptor antagonist TNF-R1 and IL-1RA in patients with DF or DHF. Hospitalized patients were randomized to receive standard supportive care or supportive care combined with doxycycline or tetracycline therapy. Serum cytokine and cytokine receptor/antagonist levels were determined at the onset of therapy and after 3 and 7 days. Cytokine and cytokine receptor/antagonist levels were substantially elevated at day 0. IL-6, IL-1β, and TNF remained at or above day 0 levels throughout the study period in untreated patients. Treatment with tetracycline or doxycycline resulted in a significant decline in cytokine levels. Similarly, IL-1RA and TNF-R1 serum concentrations were elevated at baseline and showed a moderate increase among untreated patients. Both drugs resulted in a significant rise in IL-1Ra levels by day 3 in patients. In contrast, treatment did not affect a similar result for TNF-R1. When compared to the control group, however, a significant rise post-treatment was seen upon intragroup analysis. Further analysis demonstrated that doxycycline was significantly more effective at modulating cytokine and cytokine receptor/antagonist levels than tetracycline. |
| Databáze: | OpenAIRE |
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