COVID-19 associated with encephalomyeloradiculitis and positive anti-aquaporin-4 antibodies: Cause or coincidence?
| Autor: | Daniel da Cruz Bezerra, Antônio Carlos Coutinho, Luiz Celso Hygino da Cruz, F. S. Lima, Diogo Goulart Corrêa |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Azathioprine
medicine.disease_cause Autoimmune Diseases Autoimmunity Pathogenesis 03 medical and health sciences 0302 clinical medicine medicine Humans Encephalomyelitis Radiculopathy Neuroinflammation Autoantibodies 030304 developmental biology Aquaporin 4 0303 health sciences Neuromyelitis optica Plasma Exchange business.industry Multiple sclerosis Neuromyelitis Optica Autoantibody Brain COVID-19 Middle Aged medicine.disease Magnetic Resonance Imaging Spine Neurology Immunology Female Neurology (clinical) business Immunosuppressive Agents 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Multiple Sclerosis Journal. 27:973-976 |
| ISSN: | 1477-0970 1352-4585 |
| DOI: | 10.1177/1352458520949988 |
| Popis: | Neurologic complications are being recognized as important outcomes of coronavirus disease 2019 (COVID-19). Pathogenesis is varied and incompletely understood, and may include neuroinvasion, indirect post-infectious neuroinflammation, and cerebrovascular pathologies. We present a case of COVID-19-related encephalomyeloradiculitis with clinical and magnetic resonance imaging characteristics of neuromyelitis optica spectrum disorders that was associated with anti-aquaporin-4 antibodies. Our case suggests post-infectious autoimmunity as a mechanism in at least a subset of patients with COVID-19-related neurologic disease. |
| Databáze: | OpenAIRE |
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