Association of Fusobacterium nucleatum infection and colorectal cancer: A Mexican study
| Autor: | Claudia C. Calzada-Mendoza, D.A. Comoto-Santacruz, H. Cuellar-Gómez, M.E. Ocharán-Hernández |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Oncology
medicine.medical_specialty Carcinogenesis Colorectal cancer Colonoscopy Inflammation Disease Gut flora Immune system Internal medicine Tumor Microenvironment medicine Humans Fusobacterium nucleatum medicine.diagnostic_test biology business.industry Cancer General Medicine medicine.disease biology.organism_classification digestive system diseases stomatognathic diseases Fusobacterium Infections Cytokines medicine.symptom Colorectal Neoplasms business |
| Zdroj: | Revista de Gastroenterología de México (English Edition). 87:277-284 |
| ISSN: | 2255-534X |
| DOI: | 10.1016/j.rgmxen.2021.07.001 |
| Popis: | Introduction and aims Colorectal cancer (CRC) is the third most prevalent cancer worldwide. Many risk factors are involved, and current evidence links the gut microbiota and colorectal carcinogenesis. Fusobacterium nucleatum (F. nucleatum) is proposed as one of the risk factors at the onset and during the progression of CRC, due to immune system and inflammatory modulation. Materials and methods Ninety samples from three different regions of the colon were collected through colonoscopy in patients with CRC, and qPCR TagMan® was conducted to detect F. nucleatum and cytokines (IL-17, IL-23, and IL-10) in tumor, peritumor, and normal samples. The differences between them were analyzed and correlated. Results The abundance of F. nucleatum determined through the 2-ΔΔCt method in CRC (7.750 [5.790-10.469]) was significantly higher than in the normal control (0.409 [0.251-0.817]) (p 0.05). Conclusions CRC is a heterogeneous disease that presents and progresses in a complex microenvironment, partially due to gut microbiome imbalance. F. nucleatum was enriched in CRC tissue, but whether that is a cause of the pathology or a consequence, has not yet been clearly defined. |
| Databáze: | OpenAIRE |
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