Heat shock protein-27 attenuates foam cell formation and atherogenesis by down-regulating scavenger receptor-A expression via NF-κB signaling

Autor:	Justin W. Caravaggio, Yong Xiang Chen, Tara Seibert, Joshua E. Raizman, Xiaoling Zhao, Katey J. Rayner, Tieqiang Hu, Trevor Simard, Chunhua Shi, Samira Salari, Kathryn J. Moore, Edward R. O'Brien, Dawn M. E. Bowdish, Benjamin Hibbert, Charles M. Cuerrier, Xiaoli Ma
Rok vydání:	2013
Předmět:	Apolipoprotein E medicine.medical_specialty Cell HSP27 Heat-Shock Proteins CHO Cells Biology Diet High-Fat Cell Line chemistry.chemical_compound Mice Apolipoproteins E Cricetulus Hsp27 In vivo Internal medicine Heat shock protein Nitriles medicine Animals Humans Sulfones Scavenger receptor Molecular Biology Aorta Heat-Shock Proteins Foam cell Mice Knockout NF-kappa B Scavenger Receptors Class A NF-κB Cell Biology Atherosclerosis Neoplasm Proteins Disease Models Animal medicine.anatomical_structure Endocrinology chemistry Gene Expression Regulation Immunology biology.protein Female Foam Cells Molecular Chaperones Signal Transduction
Zdroj:	Biochimica et biophysica acta. 1831(12)
ISSN:	0006-3002
Popis:	Previously, we showed an inverse correlation between HSP27 serum levels and experimental atherogenesis in ApoE(-/-) mice that over-express HSP27 and speculated that the apparent binding of HSP27 to scavenger receptor-A (SR-A) was of mechanistic importance in attenuating foam cell formation. However, the nature and importance of the interplay between HSP27 and SR-A in atheroprotection remained unclear. Treatment of THP-1 macrophages with recombinant HSP27 (rHSP27) inhibited acLDL binding (-34%; p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f767e0cff107f10ad7a79b6fa7cba4 https://pubmed.ncbi.nlm.nih.gov/23939398 Zobrazit plný text záznamu