Investigation of the association between miR-181b, Bcl-2 and LRIG1 in oral verrucous carcinoma
| Autor: | Yuan Li, Yiping Li, Krishna Munnee, Hong‑Zhi Quan, Zhan Gui Tang, Yue‑Hong Wang, Zhi‑Yuan Deng, Ousheng Liu, Wu Zhu |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male Cancer Research Down-Regulation Biology Biochemistry oral verrucous carcinoma 03 medical and health sciences Young Adult 0302 clinical medicine microRNA Genetics medicine Humans Bcl-2 Carcinoma Verrucous Molecular Biology miRNA Mouth Membrane Glycoproteins Oncogene Verrucous carcinoma apoptosis LRIG1 Cancer Articles Cell cycle Middle Aged medicine.disease Molecular medicine Lymphoma Up-Regulation Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology Oncology Proto-Oncogene Proteins c-bcl-2 030220 oncology & carcinogenesis Cancer research Carcinoma Squamous Cell Molecular Medicine Immunohistochemistry Female Mouth Neoplasms |
| Zdroj: | Molecular Medicine Reports |
| ISSN: | 1791-3004 1791-2997 |
| Popis: | Abnormal expression of microRNAs (miRNAs) is involved in the development of and anti‑apoptotic effects in various types of human cancer. However, miRNA‑mediated regulation of oral verrucous carcinoma (OVC) remains to be elucidated. The present study aimed to investigate the expression of miR‑181b in OVC and oral squamous cell carcinoma (OSCC). The expression levels of miR‑181b were determined using reverse transcription‑quantitative polymerase chain reaction. The expression levels of B‑cell lymphoma 2 (Bcl‑2) and leucine rich repeats and immunoglobulin like domains 1 (LRIG1), were evaluated using immunohistochemical staining. The correlation between Bcl‑2 and LRIG1 expression was determined using a Pearson correlation analysis. The expression levels of miR‑181b and Bcl‑2 in OVC were significantly higher compared with normal mucosal tissue (NM); however, lower compared with the OSCC. The key target of miR‑181b was LRIG1 and it was significantly lower in OVC tissues compared with NM tissue; however this was higher when compared with OSCC tissue. The expression levels of Bcl‑2 were correlated with expression levels of LRIG1 in OVC tissues. Therefore, LRIG1 may be associated with anti‑apoptotic function in OVC tissues. |
| Databáze: | OpenAIRE |
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