An association between urinary cadmium and urinary stone disease in persons living in cadmium-contaminated villages in northwestern Thailand: A population study
| Autor: | Pisit Limpatanachote, Somyot Krintratun, Pranee Mahasakpan, Witaya Swaddiwudhipong |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male inorganic chemicals medicine.medical_specialty Adolescent Exposed Population Urinary system Population chemistry.chemical_element Physiology Urine Biochemistry Excretion Young Adult medicine Humans education Aged General Environmental Science education.field_of_study Cadmium business.industry Environmental Exposure Middle Aged Thailand Urinary calcium Surgery Logistic Models chemistry Population study Environmental Pollutants Female Urinary Calculi business |
| Zdroj: | Environmental Research. 111:579-583 |
| ISSN: | 0013-9351 |
| DOI: | 10.1016/j.envres.2011.01.007 |
| Popis: | Excessive urinary calcium excretion is the major risk of urinary stone formation. Very few population studies have been performed to determine the relationship between environmental cadmium exposure and urinary stone disease. This population-based study examined an association between urinary cadmium excretion, a good biomarker of long-term cadmium exposure, and prevalence of urinary stones in persons aged 15 years and older, who lived in the 12 cadmium-contaminated villages in the Mae Sot District, Tak Province, northwestern Thailand. A total of 6748 persons were interviewed and screened for urinary cadmium and urinary stone disease in 2009. To test a correlation between urinary excretion of cadmium and calcium, we measured urinary calcium content in 1492 persons, who lived in 3 villages randomly selected from the 12 contaminated villages. The rate of urinary stones significantly increased from 4.3% among persons in the lowest quartile of urinary cadmium to 11.3% in the highest quartile. An increase in stone prevalence with increasing urinary cadmium levels was similarly observed in both genders. Multiple logistic regression analysis revealed a positive association between urinary cadmium levels and stone prevalence, after adjusting for other co-variables. The urinary calcium excretion significantly increased with increasing urinary cadmium levels in both genders, after adjusting for other co-variables. Elevated calciuria induced by cadmium might increase the risk of urinary stone formation in this environmentally exposed population. |
| Databáze: | OpenAIRE |
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