Risk factors for acquisition of OXA-48-producing Klebsiella pneumonia among contact patients: a multicentre study

Autor: Caroline Neulier, Alexandra Lomont, J. Merrer, B. Grandbastien, J.C. Lucet, Jean-Ralph Zahar, Delphine Hilliquin, V. Thepot Seegers, Didier Lepelletier, R. Le Guern, Anne-Marie Rogues, C. Legeay, V. Marie
Přispěvatelé: CHU Lille, Université de Lille, Centre Hospitalier Universitaire d'Angers [CHU Angers], Recherche translationnelle : relations hôte-pathogènes - EA 7366, Recherche translationelle relations hôte-pathogènes, Institut de Cancérologie de l'Ouest [Angers/Nantes] [UNICANCER/ICO], AP-HP - Hôpital Bichat - Claude Bernard [Paris], CHU de Bordeaux Pellegrin [Bordeaux], Centre hospitalier universitaire de Nantes [CHU Nantes], Centre Hospitalier Régional Universitaire [Lille] [CHRU Lille], CHU Necker - Enfants Malades [AP-HP], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier universitaire de Nantes (CHU Nantes), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)
Rok vydání: 2018
Předmět:
0301 basic medicine
Multivariate analysis
[SDV]Life Sciences [q-bio]
Mesh:Adult
0302 clinical medicine
Mesh:Risk Factors
Mesh:Case-Control Studies
030212 general & internal medicine
Mesh:Aged
Mesh:Klebsiella pneumoniae/enzymology
OXA-48
Aged
80 and over
Mesh:Klebsiella Infections/microbiology
Univariate analysis
Screening
Contact patients
Carbapenemases
Carbapenemase-producing
Risk factors
Enterobacteriaceae
General Medicine
Middle Aged
3. Good health
Klebsiella pneumoniae
Infectious Diseases
Mesh:Klebsiella Infections/epidemiology
Adult
Microbiology (medical)
medicine.medical_specialty
030106 microbiology
Mesh:Young Adult
beta-Lactamases
Young Adult
03 medical and health sciences
Mesh:Retrospective Studies
Mesh:Klebsiella pneumoniae/isolation & purification
Mesh:Middle Aged
Internal medicine
Mesh:80 and over
medicine
Humans
Aged
Retrospective Studies
business.industry
Case-control study
Retrospective cohort study
Odds ratio
medicine.disease
Confidence interval
Klebsiella Infections
Mesh:beta-Lactamases/analysis
Surgery
Mesh:Humans
Case-Control Studies
Concomitant
Klebsiella pneumonia
business
Zdroj: Journal of Hospital Infection
Journal of Hospital Infection, WB Saunders, 2018, The Journal of hospital infection, 98, pp.253-259. ⟨10.1016/j.jhin.2017.08.024⟩
Journal of Hospital Infection, 2018, The Journal of hospital infection, 98, pp.253-259. ⟨10.1016/j.jhin.2017.08.024⟩
ISSN: 0195-6701
1532-2939
DOI: 10.1016/j.jhin.2017.08.024
Popis: International audience; BACKGROUND: Cohorting carbapenemase-producing Enterobacteriaceae (CPE) carriers during hospitalization limits in-hospital spreading.OBJECTIVE: To identify risk factors for CPE acquisition among contacts of an index patient in non-cohorted populations.METHODS: A multicentre retrospective matched case-control study was conducted in five hospitals. Each contact patient (case) who acquired Klebsiella pneumoniae (KP)-OXA-48 from an index patient was compared to three contact (controls) with the same index patients matched with hospitalization in the same unit and similar exposure times.RESULTS: Fifty-one secondary cases and 131 controls were included. By univariate analysis, exposure time (odds ratio: 1.06; 95% confidence interval: 1.02-1.1; P = 0.006), concomitant infection at admission (3.23; 1.42-7.35; P = 0.005), antimicrobial therapy within the last month before hospitalization (2.88; 1.34-6.2; P = 0.007), antimicrobial therapy during the exposure time (5.36; 2.28-12.6; P
Databáze: OpenAIRE
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