Immobilization of N-Halamine Based Polycation on Nanodiamonds for High Dispersity and Enhanced Biocidal Activity
| Autor: | Xi Wang, Xuefeng Peng, Qiang Li, Huinan Chen, Xiaodong Xing, Weiwei Cao, Feng Jin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Staphylococcus aureus
Materials science 0206 medical engineering Dispersity Biomedical Engineering Nanoparticle Bioengineering Microbial Sensitivity Tests 02 engineering and technology Nanodiamonds Colloid Escherichia coli Polyamines General Materials Science Fourier transform infrared spectroscopy chemistry.chemical_classification Chemical modification General Chemistry Polymer 021001 nanoscience & nanotechnology Condensed Matter Physics Polyelectrolytes 020601 biomedical engineering Anti-Bacterial Agents chemistry Surface modification 0210 nano-technology Antibacterial activity Nuclear chemistry |
| Zdroj: | Journal of Nanoscience and Nanotechnology. 18:3126-3133 |
| ISSN: | 1533-4880 |
| Popis: | Novel bactericidal materials, polycation-based N-halamine functionalized nanodiamonds (PCN-NDs), were fabricated by coating of nanodiamonds (NDs) with quaternarized N-halamine polymers via a facile approach. Chemical modification of the particles was confirmed by FTIR, XPS and TGA. The particle diameters and dispersity of the functionalized NDs were investigated by TEM and DLS measurements. It was found that ND tight core aggregates could be broken into tiny nanoparticles with 40-50 nm through functionalization procedure, which resulted in stable colloidal dispersion solution over one month. The antibacterial tests showed that the PCN-NDs exhibited enhanced antibacterial activity against Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus) compared with their bulk counterparts. The minimum inhibitory concentration values of the as-prepared PCN-NDs are 62.5 μg/mL for both E. coli and S. aureus, even PCN-NDs eliminated nearly 100% of E. coil and S. aureus (107-108 CFU/mg nanoparticles) within 15 min. Furthermore, the as-prepared antimicrobial PCN-NDs exhibited good storage stability and regenerability. |
| Databáze: | OpenAIRE |
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