Accumulation of murine amyloid-β mimics early Alzheimer's disease
| Autor: | Alexander Bracke, Jacqueline Hofrichter, Oliver von Bohlen und Halbach, Cathleen Lange, Yosef Avchalumov, Markus Krohn, Toni Schumacher, Kristin Paarmann, Jens Pahnke, Christina Fröhlich, Thomas Brüning |
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| Rok vydání: | 2014 |
| Předmět: |
Long-Term Potentiation
Hippocampus ATP-binding cassette transporter Biology Alzheimer Disease medicine media_common.cataloged_instance Animals Cognitive Dysfunction European union Neprilysin media_common Mice Knockout Neurons Amyloid beta-Peptides Amyloidosis Long-term potentiation medicine.disease Astrogliosis Biochemistry of Alzheimer's disease Disease Models Animal Neurology (clinical) Multidrug Resistance-Associated Proteins Neuroscience |
| Zdroj: | Brain : a journal of neurology. 138(Pt 8) |
| ISSN: | 1460-2156 |
| Popis: | Amyloidosis mouse models of Alzheimer’s disease are generally established by transgenic approaches leading to an overexpression of mutated human genes that are known to be involved in the generation of amyloid-β in Alzheimer’s families. Although these models made substantial contributions to the current knowledge about the ‘amyloid hypothesis’ of Alzheimer’s disease, the overproduction of amyloid-β peptides mimics only inherited (familiar) Alzheimer’s disease, which accounts for |
| Databáze: | OpenAIRE |
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