Vitamin D receptor rs2228570 polymorphism is associated with LH levels in men exposed to anabolic androgenic steroids

Autor: Lena Ekström, Anders Rane, Mikael Lehtihet, Linda Björkhem-Bergman
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
LH
Anabolism
medicine.medical_treatment
lcsh:Medicine
Pilot Projects
Calcitriol receptor
Linkage Disequilibrium
Cohort Studies
chemistry.chemical_compound
Anabolic Agents
0302 clinical medicine
Gene Frequency
Polymorphism (computer science)
FSH
Testosterone Congeners
lcsh:QH301-705.5
Testosterone
General Medicine
Anabolic-Androgenic Steroids
Research Note
030220 oncology & carcinogenesis
Cohort
Anabolic androgenic steroid
Adult
medicine.medical_specialty
Genotype
TaqI
rs2228570
030209 endocrinology & metabolism
rs731236
Polymorphism
Single Nucleotide
General Biochemistry
Genetics and Molecular Biology
Steroid
03 medical and health sciences
Internal medicine
medicine
Humans
lcsh:Science (General)
business.industry
Hypogonadism
lcsh:R
Luteinizing Hormone
Endocrinology
chemistry
lcsh:Biology (General)
Vitamin D receptor
Receptors
Calcitriol
Follicle Stimulating Hormone
business
lcsh:Q1-390
Zdroj: BMC Research Notes, Vol 11, Iss 1, Pp 1-6 (2018)
BMC Research Notes
ISSN: 1756-0500
DOI: 10.1186/s13104-018-3173-4
Popis: Objective The primary aim of this study was to investigate the association between the vitamin D receptor polymorphisms rs2228570 (Fok1) and rs731236 (TaqI) and LH and FSH levels in relation to anabolic androgenic steroid (AAS) use. Results Two cohorts were analyzed. Cohort 1 comprised healthy volunteers given single supra-physiological doses of 500 mg testosterone (n = 25). Cohort 2 comprised 45 self-reporting AAS users. Healthy volunteers homozygous for the C-allele of the Fok1 polymorphism exhibited 30% higher LH levels than T-carriers at baseline (p = 0.04) and twice the levels 14 days after testosterone administration (p = 0.01). AAS users homozygous for the C-allele had four times higher LH levels than TT-individuals (p
Databáze: OpenAIRE
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