Association of blood lead (Pb) and plasma homocysteine: a cross sectional survey in Karachi, Pakistan
| Autor: | Mohsin Yakub, Mohammad Perwaiz Iqbal |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Hyperhomocysteinemia Homocysteine Adolescent Public Health and Epidemiology/Environmental Health Population Public Health and Epidemiology lcsh:Medicine Gastroenterology chemistry.chemical_compound Young Adult Folic Acid Internal medicine Blood plasma medicine Humans Pakistan Vitamin B12 education lcsh:Science Public Health and Epidemiology/Occupational and Industrial Medicine education.field_of_study Multidisciplinary business.industry lcsh:R Venous blood Middle Aged medicine.disease Cross-Sectional Studies Quartile chemistry Lead Pyridoxal Phosphate Immunology Population study lcsh:Q Female business Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 5, Iss 7, p e11706 (2010) |
| ISSN: | 1932-6203 |
| Popis: | BACKGROUND: High blood lead (Pb) and hyperhomocysteinemia have been found to be associated with cardiovascular disease (CVD). Mean blood Pb and mean plasma homocysteine levels have been reported to be high in Pakistani population. The objective of the present study was to assess the relationship of blood Pb to the risk of hyperhomocysteinemia in a low income urban population of Karachi, Pakistan. METHODOLOGY/PRINCIPAL FINDINGS: In a cross sectional survey, 872 healthy adults (355 males, 517 females; age 18-60 years) were recruited from a low income urban population of Karachi. Fasting venous blood was obtained and assessed for blood Pb and plasma/serum homocysteine, folate, pyridoxal phosphate (PLP, a coenzymic form of vitamin B6) and vitamin B12. The study population had median (IQR) blood Pb of 10.82 microg/dL (8.29-13.60). Prevalence of high blood Pb (levels>10 microg/dL) was higher in males compared to females (62.5% males vs 56% females; p value=0.05). Mean+/-SD/median (IQR) value of plasma homocysteine was significantly higher in the highest quartile of blood Pb compared to the lowest quartile 16.13+/-11.2 micromol/L vs 13.28+/-9.7micromol/L/13.15 (10.33-17.81) micromol/L vs 11.09 (8.65 14.31) micromol/L (p value |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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